Sun Z J, Fan J N, Yu C Q, Guo Y, Bian Z, Pei P, Du H D, Chen J S, Chen Z M, Lyu J, Li L M
Department of Epidemiology and Biostatistics, School of Public Health, Peking University/Peking University Center for Public Health and Epidemic Preparedness & Response/Peking University Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China.
Chinese Academy of Medical Sciences, Beijing 100730, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2021 May 10;42(5):755-762. doi: 10.3760/cma.j.cn112338-20200305-00259.
To describe the prevalence of multimorbidity and its secular trend, and to explore the common patterns of multimorbidity in Chinese adults. A total of 25 033 participants who attended the second resurvey of China Kadoorie Biobank (CKB) were included in the study. We used data collected both at baseline (2004-2008) and at resurvey (2013-2014). A total of 13 chronic conditions were included, defined by self-reported, physical examination, and blood sample testing. Multimorbidity was defined as co-existence of two or more chronic conditions. Patterns of multimorbidity were explored using hierarchical cluster analysis. The mean age of participants was (51.5±10.1) years at baseline and (59.5±10.2) years at second resurvey. The prevalence of multimorbidity increased from 33.5% to 58.1% over (8.0±0.8) years of follow-up. The average number of chronic conditions per person increased from 1.15 to 1.82 and all participants increased 0.42 conditions per 5 years on average. Participants who were older, less educated or lived in urban areas had a higher prevalence of multimorbidity and a higher increase in the number of chronic conditions. The increase in the number of chronic conditions was also higher among smokers and heavy alcohol drinkers. The most common multimorbidity pattern in the present population consisted of obesity, hypertension, diabetes, stroke, and heart disease. The prevalence of multimorbidity in Chinese adults is increasing rapidly due to ageing population. Populations of different sociodemographic background and lifestyle habits may have different prevalence of multimorbidity and changes in rates over time.
描述多重疾病的患病率及其长期趋势，并探索中国成年人多重疾病的常见模式。共有25033名参加中国嘉道理生物银行（CKB）第二次再调查的参与者被纳入研究。我们使用了在基线期（2004 - 2008年）和再调查期（2013 - 2014年）收集的数据。总共纳入了13种慢性病，通过自我报告、体格检查和血液样本检测来定义。多重疾病被定义为两种或更多种慢性病并存。使用层次聚类分析探索多重疾病模式。参与者在基线期的平均年龄为（51.5±10.1）岁，在第二次再调查时为（59.5±10.2）岁。在（8.0±0.8）年的随访中，多重疾病的患病率从33.5%增加到58.1%。人均慢性病数量从1.15增加到1.82，所有参与者平均每5年增加0.42种疾病。年龄较大、受教育程度较低或居住在城市地区的参与者多重疾病患病率较高，慢性病数量增加也较多。吸烟者和重度饮酒者的慢性病数量增加也更高。当前人群中最常见的多重疾病模式包括肥胖、高血压、糖尿病、中风和心脏病。由于人口老龄化，中国成年人多重疾病的患病率正在迅速上升。不同社会人口背景和生活方式习惯的人群多重疾病患病率以及随时间变化的速率可能有所不同。
