Du H, Wang W, Cong Y L, Zhang J P, Guo Y, Zhang Z G, Li Q
Institute for Immunization Planning and Management, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050000, China.
Department of Hepatic-biliary-pancreatic-splenic Surgery, The First Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2021 Jun 10;42(6):1012-1017. doi: 10.3760/cma.j.cn112338-20200904-01128.
To understand the epidemiological and genotypic characteristics of imported cases of measles virus of D8 genotype in Hebei province. Epidemiological investigation of measles cases in surveillance was carried out. The throat swabs of the measles cases in acute phase were collected for real time RT-PCR identification, measles virus culture and genotype identification. A total of 36 imported measles cases of genotype D8 were detected. The cases were mainly distributed in 8 counties of Handan city. Number of confirmed measles cases in Cheng'an county was the highest, accounting for 58.33% (21/36) of all the reported cases. All patients had fever and rash, and 55.55% (20/36) of the cases were under 2 years old and 86.11% (31/36) of the cases had no immunization history. The children with pneumonia accounted for 44.12% (15/34) of the total children with D8 genotype measles virus infection. The nucleotide and amino acid homologies between the imported measles virus genotype D8 and the WHO reference strain of D8 genotype (D8-Manchester.UNK/30.94) were 98.4%-98.6% and 97.3%, respectively. Compared with the strains of H1 genotype in China, the nucleotide and amino acid homologies were 92.8%-93.1% and 93.3%, respectively. The imported cases of measles virus of D8 genotype might have caused local transmission in Hebei province. Molecular epidemiological surveillance for measles virus needs to be further strengthened. It is necessary to detect and control the epidemic early and improve the coverage rate and timely rate of measles vaccination. It is also important to prevent cross infection in hospitals.
了解河北省D8基因型麻疹病毒输入病例的流行病学和基因特征。对监测中的麻疹病例进行了流行病学调查。采集急性期麻疹病例的咽拭子进行实时RT-PCR鉴定、麻疹病毒培养和基因分型鉴定。共检测到36例D8基因型输入性麻疹病例。病例主要分布在邯郸市8个县。成安县确诊麻疹病例数最多，占报告病例总数的58.33%（21/36）。所有患者均有发热和皮疹，55.55%（20/36）的病例年龄在2岁以下，86.11%（31/36）的病例无免疫史。感染D8基因型麻疹病毒的儿童中肺炎患儿占44.12%（15/34）。输入的D8基因型麻疹病毒与世界卫生组织D8基因型参考株（D8-Manchester.UNK/30.94）的核苷酸和氨基酸同源性分别为98.4%-98.6%和97.3%。与我国H1基因型毒株相比，核苷酸和氨基酸同源性分别为92.8%-93.1%和93.3%。D8基因型麻疹病毒输入病例可能在河北省引起了局部传播。需要进一步加强麻疹病毒的分子流行病学监测。有必要尽早发现和控制疫情，提高麻疹疫苗接种的覆盖率和及时率。预防医院内交叉感染也很重要。
