Luo M, Gong C, Luo Q, Li A H, Wang X, Li M Z, Xie H, Wang Y T, Zhang H R, Huang F
Department of Immunization, Beijing Center for Disease Prevention and Control/Beijing Research Center for Preventive Medicine,Beijing 100013, China.
School of Public Health,Capital Medical University, Beijing 100069, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2021 Aug 10;42(8):1466-1474. doi: 10.3760/cma.j.cn112338-20210522-00421.
To analyze the epidemiological characteristics of infection among patients with acute respiratory infection in Beijing from 2015 to 2019. The epidemiological data of acute respiratory infection patients from 35 sentinel hospitals in Beijing were collected by the respiratory pathogen surveillance system in Beijing. The clinical samples were collected to detect , and the sequence of the VD4 region of the gene in positive samples was analyzed. From January 2015 to December 2019, the overall positive rate of among patients with acute respiratory infection in Beijing was 0.34% (129/37 460). The positive rate of generally increased in March, reaching the peak in May, and started to drop in July, with a duration of about 5-8 months. The epidemic season in different years fluctuated by 1-2 months. The positive monthly rate of was no less than 0.30% in every epidemic season. The positive rate of was the highest in the 5-44 years old group and the highest in 10-14 year-olds. The risk of infection increased with age in patients younger than 25 years old and decreased in those older one aged than 25 years of age. The positive rates in male and female patients were 0.33% (68/20 830) and 0.37% (61/16 528), respectively, and there was no significant difference between the two groups (=0.486, =0.486). The positive rate of in patients with common pneumonia was higher than that in patients with upper pneumonia and severe pneumonia (=36.797, <0.01). Other respiratory pathogens were also detected in the samples, and the top four pathogens appeared as (15 cases), (13 cases), (8 cases), and (7 cases). 101 strains of 129 positive samples were identified as type A by sequencing. The annual epidemic pattern of in Beijing, is unimodal, and the epidemic season generally appears from March to July. The seasonal characteristics of in Beijing can be used for the differential diagnosis of from other respiratory pathogens. is most common in people aged 5-44 years, and the primary genotype is type A. People aged 10-44 years old suffer the highest incidence. If the nucleic acid positive rate of exceeds 0.30% for two consecutive months, the high prevalence period of can be preliminarily expected. infection has a higher probability of progressing to severe pneumonia from general pneumonia.
分析2015年至2019年北京急性呼吸道感染患者中[病原体名称]感染的流行病学特征。通过北京呼吸道病原体监测系统收集北京35家哨点医院急性呼吸道感染患者的流行病学数据。采集临床样本进行检测，并对阳性样本中[病原体相关基因名称]基因的VD4区域序列进行分析。2015年1月至2019年12月，北京急性呼吸道感染患者中[病原体名称]的总体阳性率为0.34%（129/37460）。[病原体名称]阳性率一般在3月开始上升，5月达到峰值，7月开始下降，持续时间约5 - 8个月。不同年份的流行季节波动1 - 2个月。每个流行季节[病原体名称]的月阳性率均不低于0.30%。[病原体名称]阳性率在5 - 44岁组最高，在10 - 14岁年龄段最高。25岁以下患者中[病原体名称]感染风险随年龄增加而增加，25岁以上患者中则随年龄增加而降低。男性和女性患者的阳性率分别为0.33%（68/20830）和0.37%（61/16528），两组之间无显著差异（P = 0.486，χ² = 0.486）。普通肺炎患者中[病原体名称]的阳性率高于上肺炎和重症肺炎患者（F = 36.797，P < 0.01）。在[病原体名称]样本中还检测到其他呼吸道病原体，前四位病原体依次为[病原体名称1]（15例）、[病原体名称2]（13例）、[病原体名称3]（8例）和[病原体名称4]（7例）。129份[病原体名称]阳性样本中的101株通过测序鉴定为A型。北京[病原体名称]的年度流行模式为单峰型，流行季节一般出现在3月至7月。北京[病原体名称]的季节特征可用于与其他呼吸道病原体进行鉴别诊断。[病原体名称]在5 - 44岁人群中最常见，主要基因型为A型。10 - 44岁人群发病率最高。如果[病原体名称]核酸阳性率连续两个月超过0.30%，则可初步预计为[病原体名称]的高发期。[病原体名称]感染从普通肺炎进展为重症肺炎的概率较高。
