Yue Q, Liu Y F, Li H, Zhao Y
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2021 Oct 10;42(10):1823-1828. doi: 10.3760/cma.j.cn112338-20210331-00199.
To understand the characteristics and the first CD4T lymphocytes (CD4) test of newly-reported HIV/AIDS cases aged 50 years and above in the third round of China comprehensive AIDS response (CARES) program. The data of newly-reported HIV/AIDS cases aged 50 years and above from 2014 to 2018 were collected from the National Information system for HIV/AIDS Control and Prevention of Chinese System for Disease Control and Prevention. The Cochran-Armitage trend test and multivariate logistic regression were used for statistical analysis. There were 8 288, 9 512, 11 315, 13 091, and 14 673 newly-reported cases of HIV/AIDS aged 50 years and above in the third round of China CARES in 2014, 2015, 2016, 2017, and 2018, respectively, for a total of 56 879 cases. The majority of cases were male (75.7%). The main route of transmission was heterosexual transmission (87.8%). Most of the cases were diagnosed by medical institutions (68.6%). 69.6% of HIV/AIDS cases completed the first CD4 test within 10 working days after the diagnosis of HIV infection. Among the 29 078 HIV/AIDS cases who had their first CD4 test immediately after diagnosis of HIV infection, the proportions of CD4 cell count <200 cells/μl and <500 cells/μl were 66.5% and 93.8%, respectively. The results of logistic regression analysis of the factors related to the first CD4 test immediately showed that, compared to cases with an education level of elementary school and below, (95%) values for timely CD4 testing of cases with an education level of junior high school, high school or technical secondary school and junior college or above were 1.113 (1.063-1.166), 1.205 (1.128-1.289) and 1.277 (1.160-1.406) respectively. Compared to cases aged 50-59 years, (95%) values for timely CD4 testing of cases aged 70-79 years and ≥80 years were 0.864 (0.816-0.914) and 0.612 (0.554-0.676), respectively. Compared to cases diagnosed by HIV voluntary counseling and testing, (95%) value for timely CD4 testing of cases diagnosed by medical institutions was 0.750 (0.714-0.788). The number of newly reported HIV/AIDS cases aged 50 and above was increasing year by year in the third round of China CARES, with a predominance of men and previous infections. The proportion of timely CD4 tests was drastically increasing. The factors associated with timely CD4 test included primary school or below education level, ≥70 years old, and cases diagnosed by medical institutions. The third round of China CARES should focus on strengthening the prevention of AIDS and early detection of HIV/AIDS cases among the elderly.
了解中国第三轮综合艾滋病防治(CARES)项目中50岁及以上新报告艾滋病病毒(HIV)/艾滋病病例的特征及首次CD4T淋巴细胞(CD4)检测情况。从中国疾病预防控制信息系统的全国艾滋病防治信息系统中收集2014年至2018年50岁及以上新报告HIV/AIDS病例的数据。采用 Cochr an - Armitage趋势检验和多因素logistic回归进行统计分析。2014年、2015年、2016年、2017年和2018年中国第三轮CARES项目中50岁及以上新报告HIV/AIDS病例数分别为8288例、9512例、11315例、13091例和14673例,共计56879例。大多数病例为男性(75.7%)。主要传播途径为异性传播(87.8%)。大多数病例由医疗机构诊断(68.6%)。69.6%的HIV/AIDS病例在确诊HIV感染后10个工作日内完成了首次CD4检测。在确诊HIV感染后立即进行首次CD4检测的29078例HIV/AIDS病例中,CD4细胞计数<200个/μl和<500个/μl的比例分别为66.5%和93.8%。首次CD4检测相关因素的logistic回归分析结果显示,与小学及以下文化程度病例相比,初中、高中或中专以及大专及以上文化程度病例及时进行CD4检测的(95%)值分别为1.113(1.063 - 1.166)、1.205(1.128 - 1.289)和1.277(1.160 - 1.406)。与50 - 59岁病例相比,70 - 79岁和≥80岁病例及时进行CD4检测的(95%)值分别为0.864(0.816 - 0.914)和0.612(0.554 - 0.676)。与通过HIV自愿咨询检测确诊的病例相比,由医疗机构确诊的病例及时进行CD4检测的(95%)值为0.750(0.714 - 0.788)。中国第三轮CARES项目中50岁及以上新报告HIV/AIDS病例数逐年增加,以男性和既往感染为主。及时进行CD4检测的比例大幅上升。与及时进行CD4检测相关的因素包括小学及以下文化程度、≥70岁以及由医疗机构诊断的病例。中国第三轮CARES项目应重点加强老年人艾滋病预防及HIV/AIDS病例的早期发现。