社区居住的老年人群中收缩压和舒张压与全因死亡率的相关性：一项前瞻性观察研究。

Association of Systolic and Diastolic Blood Pressure With All-Cause Mortality Among Community-Dwelling Older Adults: A Prospective Observational Study.

机构信息

37581Singapore General Hospital, Singapore.

Program in Health Services and Systems Research, 121579Duke-NUS Medical School, Singapore.

出版信息

J Aging Health. 2022 Aug-Sep;34(4-5):674-683. doi: 10.1177/08982643211055245. Epub 2021 Nov 23.

DOI:10.1177/08982643211055245

PMID:34814767

Abstract

OBJECTIVES

To assess the association of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with mortality among older adults in Singapore.

METHODS

Association of SBP and DBP measured in 2009 for 4443 older adults (69.5±7.4 years; 60-97 years) participating in a nationally representative study with mortality risk through end-December 2015 was assessed using Cox regression.

RESULTS

Higher mortality risk was observed at the lower and upper extremes of SBP and DBP. With SBP of 100-119 mmHg as the reference, multivariable mortality hazard ratios [HRs (95% confidence interval)] were SBP <100 mmHg: 2.41 (1.23-4.72); SBP 160-179 mmHg: 1.51 (1.02-2.22); and SBP ≥180 mmHg: 1.78 (1.12-2.81). With DBP of 70-79 mmHg as the reference, HRs were DBP <50 mmHg: 2.41 (1.28-4.54) and DBP ≥110 mmHg: 2.16 (1.09-4.31).

DISCUSSION

Management of high blood pressure among older adults will likely reduce their mortality risk. However, the association of excessively low SBP and DBP values with mortality risk needs further evaluation.

摘要

目的

评估新加坡老年人的收缩压（SBP）和舒张压（DBP）与死亡率之间的关系。

方法

使用 Cox 回归评估了 2009 年测量的 4443 名老年人（69.5±7.4 岁；60-97 岁）的 SBP 和 DBP 与 2015 年 12 月底前的死亡率风险之间的关系，这些老年人参加了一项全国代表性研究。

结果

在 SBP 和 DBP 的较低和较高极端值观察到较高的死亡率风险。以 SBP 为 100-119mmHg 为参考，多变量死亡率风险比[HR（95%置信区间）]为 SBP<100mmHg：2.41（1.23-4.72）；SBP 为 160-179mmHg：1.51（1.02-2.22）；和 SBP≥180mmHg：1.78（1.12-2.81）。以 DBP 为 70-79mmHg 为参考，HR 分别为 DBP<50mmHg：2.41（1.28-4.54）和 DBP≥110mmHg：2.16（1.09-4.31）。