Azizian Amir Reza, Carr Tracey, Muhajarine Nazeem, Verrall Tanya, Hartness Collin, Vanstone Jason, Yasinian Maryam, Skrapek Candace, Andreas Brenda, Farthing Gerald, Groot Gary
Department of Community Health and Epidemiology (Azizian, Carr, Muhajarine, Yasinian, Groot), College of Medicine, University of Saskatchewan; Saskatchewan Health Quality Council (Verrall), Saskatoon, Sask.; Saskatchewan Health Authority (Azizian, Groot, Hartness, Vanstone), Regina, Sask.; patient partner (Skrapek), Saskatoon, Sask.; patient partner (Andreas), Maple Creek, Sask.; family partner (Farthing), Saskatoon, Sask.
CMAJ Open. 2021 Nov 23;9(4):E1034-E1039. doi: 10.9778/cmajo.20210041. Print 2021 Oct-Dec.
There is an urgent need to inform decision-making and safe delivery of vaccines in a timely manner. Our objective is to describe the methods we used to perform a patient-oriented realist evaluation of COVID-19 vaccination implementation in Saskatchewan, Canada, in order to understand the underlying mechanisms and contexts of vaccination implementation and vaccine uptake.
This methodology paper describes a patient-oriented, realist, mixed-method evaluation to assess COVID-19 vaccination implementation in Regina, Saskatoon and Prince Albert, Saskatchewan. The study comprised 3 iterative phases guided by Realist And Meta-narrative Evidence Synthesis: Evolving Standards II (RAMESES II). In phase 1 (January-February 2021), we developed the initial program theory, in phase 2 (March-May 2021), we tested and refined the initial program theory, and in phase 3 (June-July 2021), we established the final program theory. Three patient and family partners with different backgrounds and experiences were selected purposively from various locations (urban and rural) in Saskatchewan to engage collaboratively in the evaluation. Data analysis and synthesis occurred at all 3 phases of the project. We analysed qualitative data from phases 2 and 3 using a "retroductive" approach. We used quantitative data to compare outcomes from the 3 sites.
This protocol describes how we developed a final program theory for COVID-19 vaccination implementation with patient and family partners to show for whom, under what circumstances, how and why Saskatchewan's COVID-19 vaccination program has led to vaccine uptake. With patient and family partners' engagement, the evaluation findings will be shared with the Saskatchewan Health Authority and provincial government policy-makers and communications departments, published in peer-reviewed journals, presented at provincial or national conferences, and disseminated through any additional media identified by the patient and family partners.
迫切需要及时为决策提供信息并确保疫苗的安全接种。我们的目标是描述我们用于对加拿大萨斯喀彻温省新冠疫苗接种实施情况进行以患者为导向的现实主义评估的方法，以便了解疫苗接种实施和疫苗接种率的潜在机制及背景。
本方法学论文描述了一项以患者为导向的、现实主义的混合方法评估，以评估萨斯喀彻温省里贾纳、萨斯卡通和阿尔伯特王子城的新冠疫苗接种实施情况。该研究包括由现实主义与元叙事证据综合：不断发展的标准II（RAMESES II）指导的3个迭代阶段。在第1阶段（2021年1月至2月），我们制定了初始项目理论；在第2阶段（2021年3月至5月），我们测试并完善了初始项目理论；在第3阶段（2021年6月至7月），我们确立了最终项目理论。从萨斯喀彻温省不同地点（城市和农村）有目的地挑选了3名具有不同背景和经历的患者及家属合作伙伴，以共同参与评估。数据分析和综合在项目的所有3个阶段进行。我们使用“溯因”方法分析了第2阶段和第3阶段的定性数据。我们使用定量数据比较了3个地点的结果。
本方案描述了我们如何与患者及家属合作伙伴共同制定新冠疫苗接种实施的最终项目理论，以说明萨斯喀彻温省的新冠疫苗接种计划针对哪些人群、在何种情况下、如何以及为何导致了疫苗接种。通过患者及家属合作伙伴的参与，评估结果将与萨斯喀彻温省卫生局以及省政府政策制定者和宣传部门分享，发表在同行评审期刊上，在省级或国家级会议上展示，并通过患者及家属合作伙伴确定的任何其他媒体进行传播。
