Regional Centre for Endocrinology and Diabetes Royal Victoria Hospital, Belfast.
Department of Endocrine and Diabetes, Belfast City Hospital, Belfast, UK.
Ulster Med J. 2021 Sep;90(3):146-150. Epub 2021 Nov 11.
The pituitary gland is an unusual site for metastatic spread and has been associated with a poor prognosis. Clinical presentation is variable but can include visual field defects, cranial nerve palsies, anterior pituitary dysfunction and/ or diabetes insipidus. Management options include surgery or radiotherapy, chemotherapy/immunotherapy or a conservative approach. The pituitary should not be overlooked as a site for metastasis in patients with known cancer and can be the first presentation of neoplastic disease in some patients. Given that patients are now living longer with cancer, clinicians should be alert to the varied presentation of pituitary metastasis. We provide a clinical overview of pituitary metastasis with the aid of illustrative clinical cases.
垂体是转移的罕见部位，与预后不良有关。临床表现多样，但可能包括视野缺损、颅神经麻痹、垂体前叶功能障碍和/或尿崩症。治疗选择包括手术或放疗、化疗/免疫疗法或保守治疗。对于已知患有癌症的患者，垂体不应被忽视为转移部位，并且在某些患者中可能是肿瘤疾病的首发表现。鉴于患者现在能更长时间地存活于癌症，临床医生应警惕垂体转移的各种表现。我们通过举例说明的临床病例提供了对垂体转移的临床概述。
