Sallé Guillaume, Deiss Véronique, Marquis Céline, Tosser-Klopp Gwenola, Cortet Jacques, Serreau Delphine, Koch Christine, Marcon Didier, Bouvier Frédéric, Jacquiet Philippe, Blanchard Alexandra, Mialon Marie-Madeleine, Moreno-Romieux Carole
INRAE UMR1282 ISP U. de Tours Nouzilly France.
INRAE VetAgro Sup UMRH F-63122 Saint-Genès-Champanelle U. Clermont Auvergne Theix France.
Evol Appl. 2021 Sep 15;14(11):2591-2602. doi: 10.1111/eva.13294. eCollection 2021 Nov.
Drug-resistant parasites threaten livestock production. Breeding more resistant hosts could be a sustainable control strategy. Environmental variation linked to animal management practices or to parasite species turnover across farms may however alter the expression of genetic potential. We created sheep lines with high or low resistance to and achieved significant divergence on both phenotypic and genetic scales. We exposed both lines to chronic stress or to the infection by another parasite , to test for genotype-by-environment and genotype-by-parasite species interactions respectively. Between-line divergence remained significant following chronic stress exposure although between-family variation was found. Significant genotype-by-parasite interaction was found although -resistant lambs remained more resistant against . Growth curves were not altered by the selection process although resistant lambs were lighter after the second round of divergence, before any infection took place. Breeding for resistance is a sustainable strategy but allowance needs to be made for environmental perturbations and worm species.
耐药寄生虫威胁着畜牧业生产。培育更具抗性的宿主可能是一种可持续的控制策略。然而，与动物管理实践相关的环境变异或农场间寄生虫物种更替可能会改变遗传潜力的表达。我们培育了对[寄生虫名称1]具有高抗性或低抗性的绵羊品系，并在表型和遗传尺度上实现了显著差异。我们使两个品系都暴露于慢性应激或感染另一种寄生虫[寄生虫名称2]，分别测试基因型与环境以及基因型与寄生虫物种之间的相互作用。尽管发现了家系间变异，但在暴露于慢性应激后，品系间差异仍然显著。尽管对[寄生虫名称1]具有抗性的羔羊对[寄生虫名称2]仍具有更高的抗性，但发现了显著的基因型与寄生虫相互作用。尽管在第二轮分化后，即在任何感染发生之前，抗性羔羊体重较轻，但生长曲线并未因选择过程而改变。培育抗性是一种可持续的策略，但需要考虑环境扰动和蠕虫物种的影响。
