单卵双胞胎中的多重自身免疫和表位扩展
Multiple autoimmunity and epitope spreading in monozygotic twins.
作者信息
Avalos-Díaz Esperanza, Pérez-Pérez Elena, Granados Julio, Pacheco-Tovar Deyanira, Bollain-Y-Goytia-de-la-Rosa Juan-José, Herrera-Esparza Rafael
机构信息
Universidad Autónoma de Zacatecas, Department of Immunology, UACB. Guadalupe, Zac, Mexico.
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Department of Transplantation, Mexico City, Mexico.
出版信息
J Transl Autoimmun. 2021 Nov 6;4:100132. doi: 10.1016/j.jtauto.2021.100132. eCollection 2021.
We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB104-DQB103:02 and HLA-DRB103-DQB10201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibodies. A critical review is presented regarding the role of MHC II molecules linked to clinical manifestations of various autoimmune diseases displayed in a single patient, as is the case in the twin patients reported here.
我们报告了一组患有自身免疫性甲状腺炎和白癜风的同卵男性双胞胎患者的临床、血清学和免疫遗传学研究，这些患者与HLA - DRB104 - DQB103:02和HLA - DRB103 - DQB10201单倍型相关。患者体内可检测到抗甲状腺和抗黑素细胞自身抗体。本文对与单一患者所表现出的各种自身免疫性疾病临床表现相关的MHC II类分子的作用进行了批判性综述，本文报道的双胞胎患者便是如此。
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