Department of Nutrition and Food Science, University of Tabuk, Tabuk, Saudi Arabia.
Department of Home Economics, Faculty of Specific Education, Kafrelsheikh University, Kafr El-Shaikh, Egypt.
J Food Biochem. 2022 Jan;46(1):e14017. doi: 10.1111/jfbc.14017. Epub 2021 Nov 23.
Coffee is among the most commonly consumed beverage all over the world. Studies have increasingly suggested caffeine and coffee as effective therapeutic interventions against Alzheimer's disease (AD). We have therefore utilized the aluminum chloride rat model for AD to compare the influence of moderately caffeinated (Arabian) and decaffeinated (Date palm seed) coffee on cognitive impairment and pathological events in AD. AD rats given Arabian or Date palm seed coffee were protected against memory impairment and had lower serum levels of the abnormal protein (amyloid-beta; Aβ1-42), the central pathogenic contributor to AD, and transforming growth factor-beta (TGF-β). Interestingly, Date palm seed (decaffeinated) coffee seems to provide more pronounced protection against AD than Arabian (moderately caffeinated) coffee as evidenced by the greater decrease in serum Aβ levels. These results suggest a surprising therapeutic potential of moderate caffeine intake in Arabian coffee to ameliorate AD through decreasing serum Aβ levels. However, Date palm seed (decaffeinated) coffee, rich in flavonoids, appears to provide a better AD-modifying ability through a direct reduction of Aβ production. PRACTICAL APPLICATIONS: Consumption of moderately caffeinated Arabian coffee attenuated AD-induced cognitive impairment via its anti-amyloidogenic potential, decreasing Aβ levels. Moreover, intake of decaffeinated Date seed extract, rich in flavonoids, exerted a superior anti-AD potential through a direct reduction of Aβ production. Both of them were also safe and maintained hepatic and renal functions in a rat model of AlCl -induced AD. Further clinical studies are warranted to confirm current results and to recommend the regular drinking of Arabian coffee or Date seed extract as a protective approach to delay AD progression in vulnerable individuals or in early disease stages.
咖啡是全世界最常饮用的饮料之一。越来越多的研究表明，咖啡因和咖啡是治疗阿尔茨海默病（AD）的有效治疗手段。因此，我们利用氯化铝致 AD 大鼠模型，比较了适度含咖啡因（阿拉伯咖啡）和脱咖啡因（椰枣种子咖啡）咖啡对 AD 认知障碍和病理事件的影响。给予阿拉伯咖啡或椰枣种子咖啡的 AD 大鼠可预防记忆障碍，并降低异常蛋白（淀粉样蛋白-β；Aβ1-42）的血清水平，淀粉样蛋白-β是 AD 的主要致病物质，以及转化生长因子-β（TGF-β）。有趣的是，椰枣种子（脱咖啡因）咖啡似乎比阿拉伯咖啡（适度含咖啡因）提供了更显著的 AD 保护作用，因为血清 Aβ水平的降低更为明显。这些结果表明，阿拉伯咖啡中适度摄入咖啡因具有令人惊讶的治疗 AD 的潜力，通过降低血清 Aβ水平来改善 AD。然而，富含类黄酮的椰枣种子（脱咖啡因）咖啡似乎通过直接减少 Aβ的产生提供了更好的 AD 修饰能力。
适度含咖啡因的阿拉伯咖啡通过其抗淀粉样变性潜力减轻 AD 引起的认知障碍，降低 Aβ水平。此外，富含类黄酮的脱咖啡因椰枣种子提取物通过直接减少 Aβ的产生，发挥出更好的抗 AD 潜力。它们都安全且维持了 AlCl 诱导的 AD 大鼠的肝肾功能。需要进一步的临床研究来证实当前的结果，并建议定期饮用阿拉伯咖啡或椰枣种子提取物作为一种保护措施，以延缓易患个体或早期疾病阶段的 AD 进展。
