Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran.
Pediatric Rheumatology Iranian Society.
Arch Iran Med. 2021 Oct 1;24(10):783-785. doi: 10.34172/aim.2021.116.
There is a possible association between celiac disease (CD) and juvenile idiopathic arthritis (JIA). Our aim was to evaluate the serological incidence of CD in patients with JIA. Children under 16 years of age with JIA who did not respond adequately to routine treatment, who referred to the pediatric centers of Tehran University of Medical Sciences (2017-2019), were enrolled in this study. Manifestations of CD were also evaluated. CD-related serological screening tests were measured. Seventy-eight patients were enrolled in the study. Their mean age was 7.9±3.9 (1.6-16) years. Three patients with oligoarticular JIA had Anti-TTG-Ab levels above normal (prevalence=3.8%). None of them had symptoms of CD. There were no significant statistical differences in terms of growth disorders, sex distribution, and different subtypes of JIA ( value ˃ 0.05) between the groups (sero-positive vs. sero-negative). In one case, CD was confirmed by pathology and the gluten-free diet was recommended. The absence of CD symptoms in patients with JIA does not rule out concomitant CD.
可能存在乳糜泻（CD）和青少年特发性关节炎（JIA）之间的关联。我们的目的是评估 JIA 患者的 CD 血清发病率。本研究纳入了 2017-2019 年期间，未对常规治疗有充分反应而转诊至德黑兰医科大学儿科中心的 16 岁以下 JIA 患儿。还评估了 CD 的表现。测量了与 CD 相关的血清学筛查试验。本研究纳入了 78 例患者。他们的平均年龄为 7.9±3.9（1.6-16）岁。3 例少关节型 JIA 患者的 Anti-TTG-Ab 水平高于正常值（患病率=3.8%）。他们均无 CD 症状。两组之间（阳性组与阴性组）在生长障碍、性别分布和 JIA 的不同亚型方面无显著统计学差异（ value ˃ 0.05）。在 1 例患者中，CD 通过病理学得到证实，并建议采用无麸质饮食。JIA 患者无 CD 症状并不能排除并发 CD。
