Creighton University School of Medicine, Omaha, NE.
Department of Pathology and Area Laboratory Services, San Antonio Military Medical Center, San Antonio, TX; and.
Am J Dermatopathol. 2022 Mar 1;44(3):e29-e32. doi: 10.1097/DAD.0000000000002103.
Dowling-Degos Disease (DDD) is a rare and disfiguring autosomal dominant genodermatosis characterized by reticulate hyperpigmented macules or follicular comedone-like papules in the intertriginous areas that typically presents in the third or fourth decade of life. It is a progressive disease that is often treatment-resistant. Although its association with hidradenitis suppurativa has been well described, DDD has also been less commonly reported in conjunction with other dermatologic diseases with unknown etiologic associations. Herein, we present a case of DDD with associated epidermal inclusion cysts and conduct a literature review of dermatologic conditions reported in association with DDD.
Dowling-Degos 病（DDD）是一种罕见的、毁容性的常染色体显性遗传性皮肤病，其特征是在皱褶部位出现网状色素沉着过度的斑片或似毛囊角栓样丘疹，通常在生命的第三或第四个十年出现。它是一种进行性疾病，通常对治疗有抵抗力。尽管其与化脓性汗腺炎的相关性已有很好的描述，但 DDD 也较少与其他具有未知病因关联的皮肤病同时发生。在此，我们报告一例伴表皮包涵囊肿的 DDD，并对与 DDD 相关的皮肤科疾病进行文献复习。
