Universidade Federal de Alagoas - UFAL, Institute of Biological Sciences and Health, Maceio, AL, Brazil.
Instituto Federal de Alagoas - IFAL, Department of Chemistry, Maceio, AL, Brazil.
Braz Oral Res. 2021 Nov 19;35:e104. doi: 10.1590/1807-3107bor-2021.vol35.0104. eCollection 2021.
This study aims to develop a nano-sized fluoridated layered double hydroxide (LDH)-based release system via hydrothermal treatment for the controlled delivery of fluoride (F-) ions in the oral environment. The synthesis of conventional LDH-type (C-LDH) precursor nanomaterials was conducted using a co-precipitation method at constant pH, and the nanoparticulate-LDH (N-LDH) was synthesized by a hydrothermal procedure. Fluoride LDH (F-LDH) products were obtained through indirect synthesis using the precursor ion-exchange technique by varying the agitation time (2 and 24 h) and temperature (25 and 40 °C) to produce 12 material samples. The materials were characterized by energy dispersive x-ray, hexamethyldisilazane, digital radiography x-ray, Fourier-transform infrared, thermogravimetric analysis, and scanning electron microscopy. Additionally, the F-release kinetic profile was evaluated for 21 d in neutral and acid media with mathematical model analysis. Products with varying F-quantities were obtained, revealing specific release profiles. In general, there was a higher F-release in the acid medium, with emphasis on F-LDH-8. Fluoride-LDH and controlled fluoride delivery was successfully obtained, proving the potential of these nanomaterials as alternative anti-caries agents.
本研究旨在通过水热处理开发一种基于纳米氟化层状双氢氧化物 (LDH) 的释放系统，以在口腔环境中控制氟离子 (F-) 的释放。采用恒 pH 值共沉淀法合成传统 LDH 型 (C-LDH) 前体纳米材料，并通过水热法合成纳米 LDH (N-LDH)。通过改变搅拌时间 (2 和 24 h) 和温度 (25 和 40°C)，采用前体离子交换技术间接合成氟 LDH (F-LDH) 产物，得到 12 种材料样品。通过能量色散 X 射线、六甲基二硅氮烷、数字射线照相术 X 射线、傅里叶变换红外、热重分析和扫描电子显微镜对材料进行了表征。此外，还通过数学模型分析评估了中性和酸性介质中 21 天的 F 释放动力学曲线。获得了具有不同 F 含量的产物，呈现出特定的释放曲线。一般来说，在酸性介质中 F 的释放量更高，F-LDH-8 尤为明显。成功获得了氟 LDH 和受控的氟释放，证明了这些纳米材料作为抗龋替代剂的潜力。
