新型含 LiAl-F 层状双氢氧化物 (LDH) 填料的牙科树脂复合材料：氟释放/再充电、机械性能、颜色变化和细胞毒性。

Novel dental resin composites containing LiAl-F layered double hydroxide (LDH) filler: Fluoride release/recharge, mechanical properties, color change, and cytotoxicity.

机构信息

Department of Materials Science and Engineering, National Chung Hsing University, Taiwan, ROC.

Department of Dental Hygiene, China Medical University, Taichung, Taiwan, ROC; School of Dentistry, College of Dentistry, China Medical University, Taichung, Taiwan, ROC; Graduate Institute of Biomedical Science, College of Medicine, China Medical University, Taichung, Taiwan, ROC; Biomaterials Translational Research Center, China Medical University Hospital, Taichung, Taiwan, ROC.

出版信息

Dent Mater. 2019 May;35(5):663-672. doi: 10.1016/j.dental.2019.02.002. Epub 2019 Mar 5.

DOI:10.1016/j.dental.2019.02.002

PMID:30850280

Abstract

OBJECTIVES

A novel LiAl-F layered double hydroxide (LDH) with a beneficial anions-exchangeable feature was developed for use as a fluoride reservoir. This study aims to investigate the fluoride release/ recharge capability of an LDH-contained dental resin composite and their effects on physical and biological properties.

METHODS

3% and 5% of LDH (R3, R5), wet-milled micro-scale LDH (R3W, R5W), or dry-milled nano-scale LDH (R3D, R5D) were added to a micro-hybrid flowable resin composite (RX). A commercial dental compomer (CC) was selected for comparison. An ion selective electrode recorded the daily fluoride release for 90 days (Daily fluoride recharging from 30th to 60th day). The flexural tests were performed according to ISO 4049. Also, the surface microhardness, color changes (L*, a*, b*), Al/Li ion leaching, and cytotoxicity were evaluated.

RESULTS

The LDH-contained resin composites show significantly increased fluoride release and recharge capability. Among them, R3 and R5 have more stable and long-term fluoride release than R3W, R5W, R3D, R5D, and CC. The LDH filler did not induce cytotoxicity, although few amounts of Al/Li ions were detected on the first day. The LDH filler did not alter the flexural strength of RX, and the microhardness (R3, R5, R3D, and R5D) was significantly higher than the CC group (P < 0.01). The LDH filler slightly increased the color of the composite in red (a* values) and yellow (b* values).

SIGNIFICANCE

The LiAl-F LDH can be a fluoride reservoir filler for dental resin composites that increases the anti-caries ability.

摘要

目的

开发了一种具有有益阴离子可交换特性的新型 LiAl-F 层状双氢氧化物（LDH），用作氟化物储存库。本研究旨在研究含 LDH 的牙科树脂复合材料的氟释放/再充电能力及其对物理和生物学性质的影响。

方法

将 3%和 5%的 LDH（R3、R5）、湿磨微尺度 LDH（R3W、R5W）或干磨纳米尺度 LDH（R3D、R5D）添加到微混合流动树脂复合材料（RX）中。选择一种商业牙科复合树脂（CC）进行比较。离子选择性电极记录了 90 天的日氟释放量（第 30 天至第 60 天的每日氟再充电）。根据 ISO 4049 进行弯曲试验。还评估了表面显微硬度、颜色变化（L*、a*、b*）、Al/Li 离子浸出和细胞毒性。

结果

含 LDH 的树脂复合材料显示出显著增加的氟释放和再充电能力。其中，R3 和 R5 的氟释放比 R3W、R5W、R3D、R5D 和 CC 更稳定且持续时间更长。尽管在第一天检测到少量的 Al/Li 离子，但 LDH 填料没有引起细胞毒性。LDH 填料没有改变 RX 的弯曲强度，并且微硬度（R3、R5、R3D 和 R5D）明显高于 CC 组（P < 0.01）。LDH 填料略微增加了复合材料的红色（a值）和黄色（b值）的颜色。