Bezmialem Vakıf University, Medical Faculty, Department of Neurology, Fatih, İstanbul, Turkey.
Bezmialem Vakıf University, Medical Faculty, Fatih, İstanbul, Turkey.
Arq Neuropsiquiatr. 2021 Dec;79(12):1084-1089. doi: 10.1590/0004-282X-ANP-2021-0003.
Although epilepsy is primarily known as a cortical disorder, there is growing body of research demonstrating white matter alterations in patients with epilepsy.
To investigate the prevalence of white matter hyperintensities (WMH) and its association with seizure characteristics in patients with epilepsy.
The prevalence of WMH in 94 patients with epilepsy and 41 healthy controls were compared. Within the patient sample, the relationship between the presence of WMH and type of epilepsy, frequency of seizures, duration of disease and the number of antiepileptic medications were investigated.
The mean age and sex were not different between patients and healthy controls (p>0.2). WMH was present in 27.7% of patients and in 14.6% of healthy controls. Diagnosis of epilepsy was independently associated with the presence of WMH (ß=3.09, 95%CI 1.06-9.0, p=0.039). Patients with focal epilepsy had higher prevalence of WMH (35.5%) than patients with generalized epilepsy (14.7%). The presence of WMH was associated with older age but not with seizure characteristics.
WMH is more common in patients with focal epilepsy than healthy controls. The presence of WMH is associated with older age, but not with seizure characteristics.
尽管癫痫主要被认为是一种皮质疾病，但越来越多的研究表明癫痫患者存在白质改变。
探讨癫痫患者白质高信号（WMH）的患病率及其与发作特征的关系。
比较了 94 例癫痫患者和 41 例健康对照者的 WMH 患病率。在患者样本中，研究了 WMH 的存在与癫痫类型、发作频率、疾病持续时间和抗癫痫药物数量之间的关系。
患者与健康对照组的平均年龄和性别无差异（p>0.2）。27.7%的患者和 14.6%的健康对照者存在 WMH。癫痫的诊断与 WMH 的存在独立相关（β=3.09，95%CI 1.06-9.0，p=0.039）。局灶性癫痫患者的 WMH 患病率（35.5%）高于全面性癫痫患者（14.7%）。WMH 的存在与年龄较大有关，但与发作特征无关。
与健康对照组相比，局灶性癫痫患者的 WMH 更常见。WMH 的存在与年龄较大有关，但与发作特征无关。
