Departament of Dermatology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Department of Pathological Anatomy, Hospital Universitario Central de Asturias, Oviedo, Spain.
Australas J Dermatol. 2022 Feb;63(1):e75-e77. doi: 10.1111/ajd.13750. Epub 2021 Nov 24.
Calciphylaxis is a potencially disorder in patients with hyperphosphatemic familial tumoral calcinosis (HFTC). Patients commonly present livedo racemosa and retiform purpura, which may progress to necrosis and very painful ulcers. Treatment with sodium thiosulfate provides good results; however, intralesional and intravenous treatment can be limited by its adverse effects. Topical sodium thiosulfate has been successfully reported for cutaneous calcification associated with connective tissue diseases and calciphylaxis in patients with chronic kidney disease. We provide a case report of a patient with HFTC and calciphylaxis who was treated with topical sodium thiosulfate with a rapid and complete response with no side effects.
钙磷乘积过高导致的家族性肿瘤性钙化症（HFTC）患者可能会发生钙磷沉积症。患者常出现网状青斑和网状紫斑，可能进展为坏死和非常疼痛的溃疡。硫代硫酸钠治疗效果良好；然而，其不良反应可能限制了局部和静脉内治疗的应用。局部硫代硫酸钠已成功用于治疗与结缔组织疾病相关的皮肤钙化和慢性肾脏病患者的钙磷沉积症。我们报告了一例 HFTC 合并钙磷沉积症患者，局部应用硫代硫酸钠治疗后迅速完全缓解，且无不良反应。
