Karamfilova Vera, Assyov Yavor, Nedeva Iveta, Gateva Antoaneta, Ivanova Irena, Cherkezov Nikolay, Mateva Ludmila, Kamenov Zdravko
Department of Internal Medicine, Clinic of Endocrinology and Metabolic Disease, University Hospital "Alexandrovska," Medical University Sofia, Sofia, Bulgaria.
Clinical Laboratory Department, University Hospital "St. Ivan Rilski," Medical University of Sofia, Sofia, Bulgaria.
Metab Syndr Relat Disord. 2022 Mar;20(2):132-136. doi: 10.1089/met.2021.0086. Epub 2021 Nov 24.
Pentraxin 3 (PTX3) is an acute-phase protein, which resembles C-reactive protein in both structure and function, and belongs to the same family. PTX3 is associated with cardiovascular diseases, obesity, and metabolic syndrome (MetS). This study evaluated the relationship between serum PTX3 levels, prediabetes, newly diagnosed type 2 diabetes mellitus (T2DM), and other biochemical and clinical parameters in obese patients with nonalcoholic fatty liver disease (NAFLD). A total of 77 obese patients with NAFLD were included. Forty-seven of them were with normal glucose levels and 30 were with glycemic disorders, including prediabetes and newly diagnosed T2DM. Serum PTX3 was measured using ELISA method. Higher PTX3 serum levels were found in patients with prediabetes and T2DM compared with those with normal blood glucose (2321.29 ± 926.63 vs. 1877.03 ± 895.45 pg/mL, = 0.028). There were significant correlations between PTX3 and alanine aminotransferase ( = 0.018), gamma-glutamyl transferase ( = 0.005), and neuropathy disability score ( < 0.05). The presence of hypertension, dyslipidemia, insulin resistance, and MetS, as well as the number of components of the MetS did not affect PTX3 levels. PTX3 serum levels were higher in an obese subject with NAFLD with prediabetes and T2DM.
五聚体蛋白3（PTX3）是一种急性期蛋白，其结构和功能与C反应蛋白相似，属于同一家族。PTX3与心血管疾病、肥胖和代谢综合征（MetS）相关。本研究评估了非酒精性脂肪性肝病（NAFLD）肥胖患者血清PTX3水平、糖尿病前期、新诊断的2型糖尿病（T2DM）与其他生化和临床参数之间的关系。共纳入77例NAFLD肥胖患者。其中47例血糖水平正常，30例存在血糖紊乱，包括糖尿病前期和新诊断的T2DM。采用酶联免疫吸附测定（ELISA）法检测血清PTX3。与血糖正常的患者相比，糖尿病前期和T2DM患者的血清PTX3水平更高（2321.29±926.63 vs. 1877.03±895.45 pg/mL，P = 0.028）。PTX3与丙氨酸氨基转移酶（P = 0.018）、γ-谷氨酰转移酶（P = 0.005）和神经病变残疾评分（P < 0.05）之间存在显著相关性。高血压、血脂异常、胰岛素抵抗和MetS的存在以及MetS的组分数量均不影响PTX3水平。患有糖尿病前期和T2DM的NAFLD肥胖患者的血清PTX3水平更高。
