Department of Orthodontics, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.
Department of Oral Surgery, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.
J Clin Periodontol. 2022 Feb;49(2):188-197. doi: 10.1111/jcpe.13577. Epub 2021 Dec 8.
Recent studies revealed that implants can migrate in bone when subjected to continuous loading. Since this process is suspected to be accompanied by bone remodelling, which requires blood vessel formation, the present work aimed at assessing the micro-angiogenic patterns around migrating implants.
In 16 rats, two customized implants were placed in a single tail vertebra and connected with contraction springs (forces: 0 N, 0.5 N, 1.0 N, 1.5 N). After 2 or 8 weeks of loading, the animals were scanned by micro-CT before and after vasculature perfusion with a silicone rubber. Vessels were segmented by subtraction of the two micro-CT scans. Vessel thickness (V.Th), vessel volume per total volume (VV/TV), and vascular spacing (V.Sp) were assessed in a peri-implant volume of interest (VOI) around each implant.
At 2 weeks of loading, force magnitude was significantly associated with VV/TV and V.Th values (χ = 10.942, p < .001 and χ = 6.028, p = .010, respectively). No significant differences were observed after 8 weeks of loading.
Within the limitations of an animal study, peri-implant vessel thickness and density were associated with force magnitude in the early loading phase, whereas effects diminished after 8 weeks of loading.
最近的研究表明，植入物在持续受力时会在骨内迁移。由于这个过程疑似伴随着需要血管形成的骨重塑，因此本研究旨在评估迁移植入物周围的微血管生成模式。
在 16 只大鼠中，将两个定制的植入物放置在单个尾椎骨中，并连接收缩弹簧（力：0 N、0.5 N、1.0 N、1.5 N）。在加载 2 或 8 周后，在血管灌注硅橡胶前后，通过 micro-CT 对动物进行扫描。通过两次 micro-CT 扫描的差值来分割血管。在每个植入物周围的植入物周围感兴趣体积（VOI）中评估血管厚度（V.Th）、血管体积与总体积比（VV/TV）和血管间距（V.Sp）。
在加载 2 周时，力的大小与 VV/TV 和 V.Th 值显著相关（χ ²= 10.942，p <.001 和 χ ²= 6.028，p =.010）。在加载 8 周后没有观察到显著差异。
在动物研究的限制范围内，植入物周围的血管厚度和密度与早期加载阶段的力大小相关，而在 8 周加载后，这种影响会减弱。
