Coriell Peter, Engledow Kevin, Roy Shailja, Smith Glenda, Nashed Nadia, Slotman Gus
375822Inspira Health Network, Vineland, NJ, USA.
Department of Surgery, 375822Inspira Health Network, Vineland, NJ, USA.
Am Surg. 2022 May;88(5):989-991. doi: 10.1177/00031348211060444. Epub 2021 Nov 24.
Squamous cell carcinoma (SCC) of the uterine cervix commonly spreads through direct infiltration and disseminates by lymphatic or hematogenous pathways. The most frequent locations for metastasis are lungs, liver, and bone. Other distant metastatic sites are rare, with only 1 reported case of neck metastasis. We present here a 73-year-old female with a prior human papillomavirus (HPV) + SCC of the cervix that had metastasized to her peri-aortic lymph nodes. Eight years after diagnosis and treatment, she returned with a hypermetabolic supraclavicular lymph node and new left-sided neck mass. Biopsy of the neck mass revealed invasive SCC positive for high-risk HPV genotype. The presence of high-risk HPV genotypes in both the cervix and supraclavicular lymph node, without evidence of second primary tumor, implies that the neck mass is a delayed metastasis of the patient's previous cervical cancer. This marks the second recorded case of neck metastasis from a SCC of the cervix.
子宫颈鳞状细胞癌（SCC）通常通过直接浸润扩散，并通过淋巴或血行途径播散。转移最常见的部位是肺、肝和骨。其他远处转移部位很少见，仅有1例颈部转移的报道。我们在此报告一名73岁女性，既往患有子宫颈人乳头瘤病毒（HPV）阳性的SCC，已转移至主动脉旁淋巴结。诊断和治疗8年后，她因锁骨上淋巴结代谢亢进和左侧颈部出现新肿块而复诊。颈部肿块活检显示为高危HPV基因型阳性的浸润性SCC。子宫颈和锁骨上淋巴结均存在高危HPV基因型，且无第二原发性肿瘤的证据，这意味着颈部肿块是患者既往宫颈癌的延迟转移。这是子宫颈SCC颈部转移的第二例有记录的病例。
