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超声引导下神经阻滞治疗手部疼痛性损伤:一项随机对照试验。

Ultrasound-Guided Nerve Blocks for Painful Hand Injuries: A Randomized Control Trial.

作者信息

Vrablik Michael, Akhavan Arvin, Murphy David, Schrepel Caitlin, Hall Michael K

机构信息

Department of Emergency Medicine, University of Washington, Seattle, USA.

出版信息

Cureus. 2021 Oct 22;13(10):e18978. doi: 10.7759/cureus.18978. eCollection 2021 Oct.

Abstract

OBJECTIVES

Traumatic hand injuries present to emergency departments frequently. Pain secondary to these injuries is typically managed with opioids, which may be inadequate and have side effects. Ultrasound (US)-guided forearm nerve blocks have emerged as an alternative modality for patients with acute pain from isolated extremity injuries.

METHODS

We performed a non-blinded, consecutive, randomized pragmatic trial of US-guided forearm nerve blocks using medium and long-acting anesthetic versus usual care for a six-day period around July 4th, 2017. Adults who sustained a traumatic or blast injury of their hands were considered. Consecutive emergency department patients were consented, enrolled and randomized into a study group (block) or control (standard care). The study group received a US-guided forearm block using a 50/50 mix of 1% lidocaine and 0.5% bupivacaine. The primary outcome was median pain scores via a 100-point visual analog scale at 15, 60, and 120 minutes after the nerve block compared to the baseline pain score. The secondary outcome was mean morphine equivalents administered.

RESULTS

Sixteen patients were screened and 12 were randomized: six to the treatment group and six to the control group. Median pain reduction from baseline at 15, 60, and 120 minutes in the forearm block group was -35 (IQR=10), -30 (IQR=50), and -20 (IQR=70, versus -5 (IQR=10), -20.5 (IQR=20), -20 (IQR=70) in the control group. At all time points, patient-reported pain scores decreased significantly over baseline in the forearm block group, whereas non-significant reductions in pain scores occurred in the control group.

CONCLUSION

US-guided forearm blocks for acute traumatic hand injuries resulted in greater pain relief when compared to usual care.

摘要

目的

创伤性手部损伤经常出现在急诊科。这些损伤引起的疼痛通常用阿片类药物治疗,但可能效果不佳且有副作用。超声(US)引导下的前臂神经阻滞已成为孤立性肢体损伤急性疼痛患者的一种替代治疗方式。

方法

我们于2017年7月4日前后进行了一项为期6天的非盲、连续、随机实用试验,比较超声引导下使用中长效麻醉剂的前臂神经阻滞与常规治疗。纳入手部遭受创伤或爆炸伤的成年人。连续的急诊科患者经同意、入组并随机分为研究组(阻滞组)或对照组(标准治疗组)。研究组接受超声引导下使用1%利多卡因和0.5%布比卡因按50/50混合液进行的前臂阻滞。主要结局指标是神经阻滞后15、60和120分钟时通过100分视觉模拟量表测得的疼痛评分中位数,并与基线疼痛评分进行比较。次要结局指标是给予的吗啡等效剂量均值。

结果

筛选出16例患者,12例被随机分组:6例进入治疗组,6例进入对照组。前臂阻滞组在15、60和120分钟时较基线的疼痛评分中位数降低值分别为-35(四分位间距[IQR]=10)、-30(IQR=50)和-20(IQR=70),而对照组分别为-5(IQR=10)、-20.5(IQR=20)、-20(IQR=70)。在所有时间点,前臂阻滞组患者报告的疼痛评分较基线均显著降低,而对照组疼痛评分降低不显著。

结论

与常规治疗相比,超声引导下的前臂阻滞用于急性创伤性手部损伤时能带来更好的疼痛缓解效果。

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