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部分上胸骨切开术保留瓣膜根部置换术的结果

Outcomes of the Valve-Sparing Root Replacement Procedure with Partial Upper Sternotomy.

作者信息

Hou Bin, Zhao Rui, Wang De, Wang Wei, Zhao Zhenhua, Sun Xiaogang, Qian Xiangyang, Yu Cuntao

机构信息

Department of Cardiovascular Surgery, Fuwai Hospital, National Centre for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100037, China.

出版信息

J Cardiovasc Dev Dis. 2021 Nov 9;8(11):154. doi: 10.3390/jcdd8110154.

Abstract

Due to better postoperative convalescence and quality of life, experienced centers focus on minimally invasive surgical techniques and approaches, but this approach is not routinely performed for valve-sparing root replacement procedures. The purpose of this study was to assess the safety and feasibility of valve-sparing root replacement via partial upper sternotomy. Between January 2016 and April 2021, 269 patients underwent a valve-sparing root replacement procedure, and partial upper sternotomy was performed in 52 patients. The clinical outcomes of the partial upper sternotomy (PUS) and complete sternotomy (CS) groups, including mortality, degree of aortic insufficiency, blood loss and consumption of blood products, postoperative complications, and hospitalization expenses, were compared. The Kaplan-Meier method was used to assess the degree of aortic regurgitation. Propensity score matching was performed as a sensitivity analysis. There was only one in-hospital death (in the CS group, = 1) and no postoperative moderate to severe aortic insufficiency in either group. The blood loss and consumption of blood products in the PUS group were also lower than in the CS group, especially for plasma use. Regarding the need for re-exploration because of bleeding, acute kidney injury, pericardial pleural effusion, drainage volume within the first 24 h, mechanical ventilation time, and arrhythmia, the two groups were comparable. Patients in the CS group showed a longer ICU time (74.20 ± 47.21 vs. 50.9 30.16 h, = 0.001) and higher hospitalization expenses (135,649.52 ± 29,992.21 vs. 123,380.15 ± 27,062.82 yuan, < 0.001). None of the patients died or reoperated during the follow-up. Freedom from moderate or severe aortic insufficiency remained comparable after matching ( = 0.97). Minimally invasive valve-sparing aortic replacement via partial upper sternotomy can be safely performed in selected patients.

摘要

由于术后恢复和生活质量更佳,经验丰富的中心专注于微创外科技术和方法,但这种方法在保留瓣膜的根部置换手术中并非常规应用。本研究的目的是评估经部分上胸骨切开术进行保留瓣膜的根部置换的安全性和可行性。2016年1月至2021年4月期间,269例患者接受了保留瓣膜的根部置换手术,其中52例患者接受了部分上胸骨切开术。比较了部分上胸骨切开术(PUS)组和完全胸骨切开术(CS)组的临床结局,包括死亡率、主动脉瓣关闭不全程度、失血量和血制品消耗量、术后并发症及住院费用。采用Kaplan-Meier法评估主动脉瓣反流程度。进行倾向评分匹配作为敏感性分析。住院期间仅1例死亡(CS组,n = 1),两组术后均无中度至重度主动脉瓣关闭不全。PUS组的失血量和血制品消耗量也低于CS组,尤其是血浆用量。在因出血、急性肾损伤、心包胸腔积液、术后24小时内引流量、机械通气时间及心律失常而需要再次手术探查方面,两组相当。CS组患者的重症监护病房(ICU)时间更长(74.20±47.21 vs. 50.9±30.16小时,P = 0.001),住院费用更高(135,649.52±29,992.21 vs. 123,380.15±27,062.82元,P < 0.001)。随访期间无患者死亡或再次手术。匹配后无中度或重度主动脉瓣关闭不全的生存率仍相当(P = 0.97)。经部分上胸骨切开术进行微创保留瓣膜的主动脉置换可在选定患者中安全实施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a42a/8618798/37825b91c7a7/jcdd-08-00154-g001.jpg

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