Kilic Kubra, Korsbæk Johanne Juhl, Jensen Rigmor H, Cvetkovic Vlasta Vukovic
Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Cephalalgia. 2022 May;42(6):524-541. doi: 10.1177/03331024211056580. Epub 2021 Nov 25.
Idiopathic intracranial hypertension is characterized by increased intracranial pressure without any pathological findings on neuroimaging, except for signs of high intracranial pressure. Before diagnosing idiopathic intracranial hypertension secondary causes of increased intracranial pressure should be excluded.
to characterize the phenotype of patients with secondary intracranial hypertension and to identify possible risk factors for secondary intracranial hypertension.
We have systematically searched the PubMed database. The publications were analyzed according to the patient phenotype, age, gender, comorbidities, body mass index/weight status, and additional medication. The results are summarized in four categories: medication, infection, hormonal induced intracranial hypertension and miscellaneous groups of diseases related to sIH.
We identified 105 eligible papers which included 272 cases. There were 49.6% pediatric cases. Among the adult group,70.9% were women. A total of 40.4% of all cases were obese or overweight, 27% among adults and 13.4% among pediatric cases. Increased BMI and recent weight gain, anemia, renal diseases and hypertension were the most frequent comorbidities related to sIH.
Among sIH patients, 40.4% were obese or overweight; two thirds were women. We recommend that even patients with a typical IIH phenotype should be screened for secondary causes.
特发性颅内高压的特征是颅内压升高，除颅内压升高的体征外，神经影像学检查无任何病理发现。在诊断特发性颅内高压之前，应排除颅内压升高的继发原因。
描述继发性颅内高压患者的表型，并确定继发性颅内高压的可能危险因素。
我们系统检索了PubMed数据库。根据患者的表型、年龄、性别、合并症、体重指数/体重状况以及其他用药情况对文献进行分析。结果归纳为四类：药物、感染、激素性颅内高压以及与继发性颅内高压相关的其他疾病组。
我们确定了105篇符合条件的论文，其中包括272例病例。儿科病例占49.6%。在成人组中，70.9%为女性。所有病例中共有40.4%肥胖或超重，成人中占27%，儿科病例中占13.4%。体重指数增加和近期体重增加、贫血、肾脏疾病和高血压是与继发性颅内高压最常见的合并症。
在继发性颅内高压患者中，40.4%肥胖或超重；三分之二为女性。我们建议，即使是具有典型特发性颅内高压表型的患者也应筛查继发原因。
