College of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, Guangdong, China.
Network & Modern Education Technology Center, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, Guangdong, China.
Int J Biol Macromol. 2022 Jan 1;194:611-618. doi: 10.1016/j.ijbiomac.2021.11.104. Epub 2021 Nov 22.
In this work, a novel sustained released system (VCSB-Zn(II)) for zinc supplements was built by vanillin-chitosan Schiff base (VCSB) chelated with Zn to improve the zinc trace element utilization ratio. Samples were characterized by FT-IR, H NMR, XRD, SEM, and TGA. The results showed that VCSB exhibited a more excellent chelation capacity of Zn than chitosan. The chelation capacity of VCSB was about 1.7 times more than that of chitosan, corresponding to 50.96 mg/g and 29.91 mg/g, respectively. Furthermore, VCSB-Zn(II) showed excellent sustained released performance at simulated gastric fluid because of the acid slow-dissolving ability. And the higher the CN content of VCSB, the higher the cumulative release rate (R) of Zn, the highest R reached 77.81%. The sustained released curves were described by the first-order and Korsmeyer-Peppas equation, which described the Zn sustained released performance caused by the dissolution of VCSB-Zn(II) and Fick diffusion. This Zn sustained released system shows great potential in the application in the field of trace elements supplements for animals.
在这项工作中，通过将香草醛-壳聚糖席夫碱（VCSB）与 Zn 螯合，构建了一种新型的锌补充剂缓释系统（VCSB-Zn(II)），以提高锌微量元素的利用率。通过傅里叶变换红外光谱（FT-IR）、核磁共振（H NMR）、X 射线衍射（XRD）、扫描电子显微镜（SEM）和热重分析（TGA）对样品进行了表征。结果表明，VCSB 对 Zn 的螯合能力优于壳聚糖。VCSB 的螯合容量约为壳聚糖的 1.7 倍，分别为 50.96mg/g 和 29.91mg/g。此外，由于酸的缓慢溶解能力，VCSB-Zn(II)在模拟胃液中表现出优异的缓释性能。并且 VCSB 的 CN 含量越高，Zn 的累积释放率（R）越高，最高可达 77.81%。缓释曲线通过一级和 Korsmeyer-Peppas 方程来描述，该方程描述了 VCSB-Zn(II)的溶解和 Fick 扩散引起的 Zn 缓释性能。这种 Zn 缓释系统在动物微量元素补充剂领域的应用中具有很大的潜力。
