Tufts University School of Medicine, Maine Medical Center, Portland, Maine.
J Arthroplasty. 2022 Aug;37(8S):S941-S946. doi: 10.1016/j.arth.2021.11.026. Epub 2021 Nov 22.
One percent to 3% of contemporary non-cemented total hip arthroplasties (THAs) present with symptomatic mechanically assisted crevice corrosion (MACC). The incidence of this problem, however, as well as the rate of asymptomatic elevations in serum cobalt, is unknown.
Cobalt and chromium levels were obtained in conjunction with radiographs at routine 10-year surveillance follow-up of THAs from a single manufacturer with a titanium stem, cobalt alloy femoral head, and cross-linked polyethylene countersurface.
Ten-year follow-up of patients with 162 consecutive THAs revealed that 17 patients with 18 hips had died of unrelated causes prior to metal ion testing. Two hips were revised for other reasons, and of the remaining 142 hips, 33 were in patients who were lost, leaving 109 hips (77% of those in alive patients and unrevised for other reasons and 67% of the entire cohort) for investigation. Sixty-three patients (58%) had a serum cobalt less than 1 ppb, and 35 (32%) a cobalt of ≥1 ppb, a cutoff consistent with MACC. Of the 32 hips with definite MACC, 15 of 32 (47%) patients were symptomatic, 16 of 30 (53%) patients had adverse local tissue reaction on magnetic resonance imaging, and 19 of 32 (59%) patients have undergone revision surgery for MACC to date.
At 10-year follow-up, a minimum of 22% (35/162) of hips had a cobalt level more than 1 ppb, consistent with MACC. Symptoms and adverse local tissue reactions are each present about one-half of the time, and 59% of those with documented MACC have undergone revision.
在当代非骨水泥全髋关节置换术中,有 1%到 3%会出现症状性机械辅助缝隙腐蚀(MACC)。然而,这个问题的发生率以及无症状钴血清升高的发生率尚不清楚。
在对同一制造商生产的钛制柄、钴合金股骨头和交联聚乙烯对置面的全髋关节进行常规 10 年随访时,结合 X 线片获取钴和铬的水平。
对 162 例连续全髋关节置换术患者的 10 年随访显示,在进行金属离子检测之前,有 17 例患者(18 髋)因其他原因死亡。两髋因其他原因翻修,在其余 142 髋中,33 髋患者失访,109 髋(存活患者且未因其他原因翻修的患者的 77%,整个队列的 67%)接受了调查。63 例患者(58%)的血清钴小于 1 ppb,35 例(32%)钴大于等于 1 ppb,这一截断值与 MACC 一致。在 32 例明确 MACC 的髋关节中,15 髋(47%)患者有症状,30 例(53%)患者的磁共振成像上有不良局部组织反应,19 髋(59%)患者因 MACC 已行翻修手术。
在 10 年随访时,至少有 35/162(22%)髋的钴水平大于 1 ppb,符合 MACC。症状和不良局部组织反应各出现约一半的时间,有记录的 MACC 患者中有 59%已行翻修手术。