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饮用水中的氟化物浓度与阿尔及利亚南部的健康风险评估。

Fluoride concentrations in drinking water and health risk assessment in the south of Algeria.

机构信息

Department of Medicine, Faculty of Medical Sciences, Kasdi Merbah University, Ouargla, 30000, Algeria; Mohamed Boudiaf Public Hospital, Ouargla, 30000, Algeria; Ouargla Technical Platform of the Center for Scientific and Technical Research in Physico-Chemical Analysis (PT-CRAPC), 30000, Ouargla, Algeria.

Annex of the National Toxicology Center, Ouargla, 30000, Algeria.

出版信息

Regul Toxicol Pharmacol. 2022 Feb;128:105086. doi: 10.1016/j.yrtph.2021.105086. Epub 2021 Nov 23.

Abstract

Drinking water is the primary source of fluoride intake by humans worldwide. Algeria, Africa's largest country, has been reported to have moderate to high fluoride levels in the water, particularly in the Southern and Saharan regions. In the south of Algeria, dental fluorosis is considered an epidemic that is spreading within the population by health professionals. This study aimed to determine fluoride concentrations in drinking water consumed by Ouargla population (south-east of Algeria) in 2021, assess non-carcinogenic health risk via daily human intake, and calculate the upper acceptable fluoride concentration in drinking water by Galgan and Vermillion formula. Forty-two water samples were collected during the spring season. The fluoride was measured using a validated spectrophotometric method. Hazard quotient of fluoride (HQ) and estimated daily intake (EDI) were calculated. The results reveal a mean fluoride level of 1.07 ± 0.38 mg/L, below WHO recommendation. Fluoride concentrations in water were higher in rural areas than in the central city (p = 0.05). HQ values were less than one for adults but greater than 1 for infants and children, suggesting health risks associated with water consumption for these vulnerable groups (p = 0.007). The main contribution of this study is the establishment of a database concerning fluoride levels and hazard quotient in the south of Algeria. Monitoring drinking water and control fluorosis is essential to avoid potential health risks.

摘要

饮用水是人类氟化物摄入的主要来源。非洲最大的国家阿尔及利亚的水中氟含量被报告为中等至高,特别是在南部和撒哈拉地区。在阿尔及利亚南部,牙氟病被认为是一种正在通过卫生专业人员在人群中传播的流行病。本研究旨在确定 2021 年阿尔及利亚东南部瓦尔格拉(Ouargla)地区居民饮用水中的氟浓度,通过人类每日摄入量评估非致癌健康风险,并根据 Galgan 和 Vermillion 公式计算饮用水中可接受的氟浓度上限。在春季共采集了 42 个水样。使用经过验证的分光光度法测量氟化物。计算氟化物的危害商数(HQ)和估计每日摄入量(EDI)。结果显示,平均值为 1.07 ± 0.38mg/L,低于世卫组织的建议值。农村地区的水氟浓度高于市中心(p = 0.05)。成人的 HQ 值小于 1,但婴儿和儿童的 HQ 值大于 1,表明这些弱势群体因饮用水而面临健康风险(p = 0.007)。本研究的主要贡献是建立了阿尔及利亚南部地区的氟水平和危害商数数据库。监测饮用水和控制氟中毒对于避免潜在的健康风险至关重要。

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