Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Department of Medical Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Science, Islamic Azad University, Tehran, Iran.
J Neuroimmunol. 2022 Jan 15;362:577768. doi: 10.1016/j.jneuroim.2021.577768. Epub 2021 Nov 17.
The aim of this study was to evaluate the therapeutic effect of PEGlated nanoliposome of pistachio unsaturated oils (PEGNLPUOs) and their efficacy to attenuate inflammation in multiple sclerosis (MS). This study was a randomized, double-blind, placebo-controlled clinical trial phase I. The level of docosahexaenoic and eicosapentaenoic acid was significantly increased and the level of matrix metallopeptidase-9 was significantly decreased in MS patients treated with PEGNLPUOs. The level of cytokine showed a Th2-biased response with attenuation of inflammation after treatment with PEGNLPUOs. The number of relapses, disability scores, and T2 lesions was significantly decreased after treatment with PEGNLPUOs.
本研究旨在评估巴旦木不饱和油聚乙二醇纳米脂质体（PEGNLPUOs）的治疗效果及其减轻多发性硬化症（MS）炎症的功效。这是一项随机、双盲、安慰剂对照的 I 期临床试验。经 PEGNLPUOs 治疗后，MS 患者二十二碳六烯酸和二十碳五烯酸水平显著升高，基质金属蛋白酶-9 水平显著降低。细胞因子水平表现出 Th2 偏向性反应，经 PEGNLPUOs 治疗后炎症得到抑制。经 PEGNLPUOs 治疗后，复发次数、残疾评分和 T2 病变显著减少。
