Qi W, Xi J H, Yang X L, Wu W, Xu Z L, Jing J F, Ni D W, Chen Y, Wang W, Zhang Y B
Department of Urology, the Second People's Hospital of Hefei, Hefei 230001, China.
Zhonghua Yi Xue Za Zhi. 2021 Nov 30;101(44):3637-3642. doi: 10.3760/cma.j.cn112137-20210325-00742.
To investigate the clinical indicators for preoperative prediction of impacted ureteral stones and analyze the predictive value of ureteral wall area(UWA). A total of 197 patients who underwent ureteroscopic lithotripsy due to ureteral stones at our institution from January to December 2020 were retrospectively analyzed. Preoperative patient age, gender, body mass index (BMI), history of hypertension, diabetes mellitus, side of stone, location of stone, maximum diameter of stone, CT value of stone, C-reactive protein (CRP), creatinine, renal pelvis diameter, ureteral wall thickness and UWA were collected. Patients were divided into impacted and non-impacted groups according to whether the stones were impacted intraoperatively. Univariate analysis was used to compare the differences in each clinical indicator between the two groups, and multivariate logistic regression was performed to analyze the independent predictors of impacted stones for those with differences. The receiver operating characteristic (ROC) curve was used to analyze the predictive power of each independent predictor, and the Delong test was used to analyze whether the difference in the area under the curve (AUC) of each independent predictor was statistically significant. All 197 patients successfully completed the operation, aged 51 (36, 56) years; 137 males and 60 females. According to the results of ureteroscopy, they were divided into 82 cases of impacted ureteral stones and 115 cases of non-impacted ureteral stones. Univariate analysis showed that there were significant differences in maximum stone diameter, stone CT value, renal pelvis diameter, ureteral wall thickness and ureteral wall area between the two groups (<0.05); There was no significant difference in age, gender, BMI, history of hypertension, diabetes, stone side, location of stone, CRP and creatinine (>0.05). Multivariate logistic regression analysis showed that stone CT value (<0.01), ureteral wall thickness (<0.001) and ureteral wall area were independent predictors of impacted ureteral stones (<0.001). The ROC curve was used to compare the predictive efficacy of independent predictors of stone CT value, ureteral wall thickness and ureteral wall area. The area under the ureteral wall area curve was the largest (AUC = 0.901, 95%: 0.859-0.943, <0.001), followed by ureteral wall thickness (AUC = 0.799, 95%: 0.736-0.862, <0.001) and stone CT value (AUC = 0.700, 95%: 0.626-0.775, <0.001). By Delong test, there were significant differences in AUC between ureteral wall area and stone CT value (=4.527, <0.001) and ureteral wall thickness (=3.407, <0.001). The best predictive value of ureteral wall area was 79.6 mm. The sensitivity and specificity of this critical value for predicting ureteral incarcerated calculi were 80.1% and 89.5%. The UWA, ureteral wall thickness as well as the CT value of stones were all independent predictors of impacted ureteral stones, and UWA had a better predictive value.
探讨术前预测输尿管结石嵌顿的临床指标,并分析输尿管壁面积(UWA)的预测价值。回顾性分析2020年1月至12月在我院因输尿管结石接受输尿管镜碎石术的197例患者。收集患者术前年龄、性别、体重指数(BMI)、高血压病史、糖尿病史、结石侧别、结石位置、结石最大直径、结石CT值、C反应蛋白(CRP)、肌酐、肾盂直径、输尿管壁厚度和UWA。根据术中结石是否嵌顿将患者分为嵌顿组和非嵌顿组。采用单因素分析比较两组各临床指标的差异,对有差异的指标进行多因素logistic回归分析,以分析嵌顿结石的独立预测因素。采用受试者工作特征(ROC)曲线分析各独立预测因素的预测能力,采用Delong检验分析各独立预测因素曲线下面积(AUC)的差异是否具有统计学意义。197例患者均成功完成手术,年龄51(36,56)岁;男性137例,女性60例。根据输尿管镜检查结果,分为输尿管结石嵌顿82例,非嵌顿115例。单因素分析显示,两组间结石最大直径、结石CT值、肾盂直径、输尿管壁厚度和输尿管壁面积差异有统计学意义(<0.05);年龄、性别、BMI、高血压病史、糖尿病史、结石侧别、结石位置、CRP和肌酐差异无统计学意义(>0.05)。多因素logistic回归分析显示,结石CT值(<0.01)、输尿管壁厚度(<0.001)和输尿管壁面积是输尿管结石嵌顿的独立预测因素(<0.001)。采用ROC曲线比较结石CT值、输尿管壁厚度和输尿管壁面积独立预测因素的预测效能。输尿管壁面积曲线下面积最大(AUC = 0.901,95%:0.859 - 0.943,<0.001),其次为输尿管壁厚度(AUC = 0.799,95%:0.736 - 0.862,<0.001)和结石CT值(AUC = 0.700,95%:0.626 - 0.775,<0.001)。经Delong检验,输尿管壁面积与结石CT值(=4.527,<0.001)和输尿管壁厚度(=3.407,<0.001)的AUC差异有统计学意义。输尿管壁面积的最佳预测值为79.6 mm。该临界值预测输尿管嵌顿结石的敏感性和特异性分别为80.1%和89.5%。输尿管壁面积、输尿管壁厚度以及结石CT值均为输尿管结石嵌顿的独立预测因素,且输尿管壁面积具有更好的预测价值。