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免疫功能低下患者的合并性角膜溃疡

Combined and Corneal Ulcer in an Immunocompromised Patient.

作者信息

Dietze Jamie, Mauger Thomas

机构信息

WVU Medicine Department of Ophthalmology, USA.

出版信息

Case Rep Ophthalmol Med. 2021 Nov 16;2021:9014667. doi: 10.1155/2021/9014667. eCollection 2021.

Abstract

Keratitis is a very common condition seen by ophthalmologists. However, many factors can complicate the treatment of this depending on the causative organism and other patient comorbid conditions. The objective of this clinical case report is to highlight the treatment of keratitis caused by . It also looks at the unique considerations in keratitis presentations for patients immunocompromised by chemotherapy agents. Our patient is a 58 yo female undergoing chemotherapy with folinic acid, fluorouracil, irinotecan, and panitumumab who presented with several days of a red, painful right eye with mucous discharge. Cultures were positive for and . The patient ultimately underwent a conjunctival flap procedure as medical therapy with proper oral and topical antibiotics failed to resolve keratitis. This case is unique as previously, only a couple of cases of keratitis caused by have been reported and none of those patients were immunocompromised nor failed antibiotic therapy.

摘要

角膜炎是眼科医生常遇到的一种非常常见的病症。然而,根据致病微生物和患者的其他合并病症,许多因素会使这种病症的治疗变得复杂。本临床病例报告的目的是突出由……引起的角膜炎的治疗方法。它还探讨了因化疗药物导致免疫功能低下的患者在角膜炎表现方面的独特考量因素。我们的患者是一名58岁女性,正在接受亚叶酸、氟尿嘧啶、伊立替康和帕尼单抗化疗,她出现右眼红肿、疼痛并伴有黏液分泌物数天。培养结果显示……呈阳性。由于使用适当的口服和局部抗生素进行药物治疗未能治愈角膜炎,该患者最终接受了结膜瓣手术。此病例很独特,因为此前仅报告过几例由……引起的角膜炎病例,且那些患者均无免疫功能低下情况,也没有抗生素治疗失败的情况。

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