Khanuja Harpreet Kaur, Dureja Harish
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India.
Recent Pat Nanotechnol. 2023;17(1):33-50. doi: 10.2174/1872210515666210719120203.
The term homogenise means "to force or provide coalesce". Homogenisation is a process to attain homogenous particle size. The objective of the homogenisation process is to use fluid force to split the fragments or tiny particles contained in the fluids into very small dimensions and form a sustainable dispersion suitable for further production.
The databases were collected through Scopus, google patent, science web, google scholar, PubMed on the concept of homogenisation. The data obtained were systematically investigated.
The present study focus on the use of the homogenisation in drug delivery system. The aim of homogenisation process is to achieve the particle size in micro-and nano- range as it affects the different parameters in the formulation and biopharmaceutical profile of the drug. The particle size reduction plays a key role in influencing drug dissolution and absorption. The reduced particle size enhances the stability and therapeutic efficacy of the drug. Homogenization technology ensures to achieve effective, clinically efficient and targeted drug delivery with the minimal side effect.
Homogenization technology has been shown to be an efficient and easy method of size reduction to increase solubility and bioavailability, stability of drug carriers. This article gives an overview of the process attributes affecting the homogenization process, the patenting of homogeniser types, design, the geometry of valves and nozzles and its role in drug delivery.
“均质化”一词意为“促使或使聚结”。均质化是一种实现均匀粒度的过程。均质化过程的目的是利用流体作用力将流体中所含的碎片或微小颗粒分裂成非常小的尺寸，并形成适合进一步生产的可持续分散体。
通过Scopus、谷歌专利、科学网、谷歌学术、PubMed收集有关均质化概念的数据库。对获得的数据进行系统研究。
本研究聚焦于均质化在药物递送系统中的应用。均质化过程的目的是实现微米和纳米级的粒度，因为它会影响药物制剂和生物药剂学特征中的不同参数。粒度减小在影响药物溶解和吸收方面起着关键作用。减小后的粒度可提高药物的稳定性和治疗效果。均质化技术确保以最小的副作用实现有效、临床高效且靶向的药物递送。
均质化技术已被证明是一种有效且简便的减小粒度的方法，可提高药物载体的溶解度、生物利用度和稳定性。本文概述了影响均质化过程的工艺属性、均质器类型的专利情况、设计、阀门和喷嘴的几何形状及其在药物递送中的作用。
