康宁木霉属生物转化的最新进展

Recent Advances in Biotransformation by Cunninghamella Species.

作者信息

Gonçalves Manoela Daiele, Tomiotto-Pellissier Fernanda, de Matos Ricardo Luís Nascimento, Assolini João Paulo, da Silva Bortoleti Bruna Taciane, Concato Virginia Marcia, Silva Taylon Felipe, Rafael Janice Aparecida, Pavanelli Wander Rogério, Conchon-Costa Ivete, Arakawa Nilton Syogo

机构信息

Laboratory of Biotransformation and Phytochemistry, Department of Chemistry, Center of Exact Sciences and Department of Pharmaceutical Sciences, Center of Health Sciences, State University of Londrina,Brazil.

Laboratory of Experimental Protozoology, Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina,Brazil.

出版信息

Curr Drug Metab. 2021;22(13):1035-1064. doi: 10.2174/1389200222666211126100023.

DOI:10.2174/1389200222666211126100023

PMID:34825868

Abstract

The goal of the biotransformation process is to develop structural changes and generate new chemical compounds, which can occur naturally in mammalian and microbial organisms, such as filamentous fungi, and represent a tool to achieve enhanced bioactive compounds. Cunninghamella spp. is among the fungal models most widely used in biotransformation processes at phase I and II reactions, mimicking the metabolism of drugs and xenobiotics in mammals and generating new molecules based on substances of natural and synthetic origin. Therefore, the goal of this review is to highlight the studies involving the biotransformation of Cunninghamella species between January 2015 and March 2021, in addition to updating existing studies to identify the similarities between the human metabolite and Cunninghamella patterns of active compounds, with related advantages and challenges, and providing new tools for further studies in this scope.

摘要

生物转化过程的目标是产生结构变化并生成新的化合物，这些变化和化合物可以在哺乳动物和微生物（如丝状真菌）体内自然发生，是实现增强生物活性化合物的一种手段。小克银汉霉属是在生物转化过程中用于I期和II期反应的最广泛使用的真菌模型之一，它模拟药物和外源性物质在哺乳动物体内的代谢，并基于天然和合成来源的物质生成新分子。因此，本综述的目的是突出2015年1月至2021年3月期间涉及小克银汉霉属生物转化的研究，除了更新现有研究以确定人类代谢物与小克银汉霉活性化合物模式之间的相似性、相关优势和挑战之外，还为该领域的进一步研究提供新工具。