Chen Jiamao, Zhang Qian, Liu Ting, Tang Hua
School of Basic Medical Sciences, Southwest Medical University, Luzhou, China.
School of Basic Medical Sciences, Southwest Medical University, Luzhou, China | Central Nervous System Drug Key Laboratory of Sichuan Province, Luzhou, China | Medicine, Engineering, Informatics Fusion and Transformation Key Laboratory, Luzhou City, China.
Curr Gene Ther. 2022;22(1):40-50. doi: 10.2174/1566523221666211126105940.
Hepatocellular carcinoma (HCC) is the sixth globally diagnosed cancer with a poor prognosis. Although the pathological factors of hepatocellular carcinoma are well elucidated, the underlying molecular mechanisms remain unclear. N-methyladenosine (MA) is adenosine methylation occurring at the N site, which is the most prevalent modification of eukaryotic mRNA. Recent studies have shown that MA can regulate gene expression, thus modulating the processes of cell self-renewal, differentiation, and apoptosis. The methyls in MA are installed by methyltransferases ("writers"), removed by demethylases ("erasers") and recognized by MA-binding proteins ("readers"). In this review, we discuss the roles of the above regulators in the progression and prognosis of HCC, and summarize the clinical association between M6A modification and hepatocellular carcinoma, so as to provide more valuable information for clinical treatment.
肝细胞癌（HCC）是全球第六大诊断出的癌症，预后较差。尽管肝细胞癌的病理因素已得到充分阐明，但其潜在的分子机制仍不清楚。N-甲基腺苷（m6A）是发生在腺苷N位点的甲基化，这是真核mRNA最普遍的修饰。最近的研究表明，m6A可以调节基因表达，从而调节细胞自我更新、分化和凋亡过程。m6A中的甲基由甲基转移酶（“书写者”）安装，由去甲基化酶（“擦除者”）去除，并由m6A结合蛋白（“阅读者”）识别。在这篇综述中，我们讨论上述调节因子在HCC进展和预后中的作用，并总结m6A修饰与肝细胞癌之间的临床关联，以便为临床治疗提供更有价值的信息。
