缺血后皮肤峰值氧饱和度与心血管危险因素相关：一项瑞典队列研究。
Post-ischemic skin peak oxygen saturation is associated with cardiovascular risk factors: a Swedish cohort study.
机构信息
Department of Biomedical Engineering, Linköping University, Linköping, Sweden.
Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
出版信息
Microvasc Res. 2022 Mar;140:104284. doi: 10.1016/j.mvr.2021.104284. Epub 2021 Nov 23.
The objective of this study was to explore the associations between skin microcirculatory function and established cardiovascular risk factors in a large Swedish cohort. As part of the Swedish CArdioPulmonary bioImage Study (SCAPIS), microcirculatory data were acquired at Linköping University hospital, Linköping, Sweden during 2016-2017. The subjects, aged 50-64 years, were randomly selected from the national population register. Microcirculatory reactivity was assessed using a 5-min arterial occlusion-release protocol. Comprehensive skin microcirculatory data were continuously acquired by using a fiberoptic probe placed on the lower right arm. After exclusion of missing data (208), 1557 subjects were remaining. Among the parameters, skin microcirculatory peak oxygen saturation after occlusion release, had the strongest relationship to the cardiovascular risk factors. The linear associations between peak oxygen saturation and cardiovascular risk factors were analyzed adjusted for age and sex. We found a negative association with peak oxygen saturation (standardized regression coefficient) for blood pressure (systolic -0.05 (95% CI: -0.10;-0.003) and diastolic -0.05 (-0.10; -0.003)), BMI -0.18 (-0.23; -0.13), waist circumference (males -0.20 (-0.32; -0.16), females -0.18 (-0.25; -0.11)), prevalent diabetes -0.31 (-0.49; -0.12), hypertension -0.30 (-0.42; -0.18), dyslipidemia -0.24 (-0.40; -0.09), fasting glucose level -0.06 (-0.12; -0.01), HbA1c -0.07 (-0.12; -0.02), triglyceride level -0.09 (-0.14; -0.04), hsCRP -0.12 (-0.17; -0.07), and current smoker versus never smoked -0.50 (-0.67; -0.34). A positive association with peak oxygen saturation was found for cholesterol level 0.05 (0.005; 0.11) and HDL 0.11 (0.06; 0.17). This is the first study showing that post-ischemic skin microvascular peak oxygen saturation is associated with virtually all established cardiovascular risk factors in a population-based middle-aged cohort.
本研究旨在探讨皮肤微循环功能与瑞典大样本队列中已确立的心血管危险因素之间的相关性。作为瑞典心肺生物影像研究（SCAPIS）的一部分，2016-2017 年间在瑞典林克平大学医院采集了微循环数据。研究对象为 50-64 岁的人群，他们是从全国人口登记处随机抽取的。通过 5 分钟的动脉闭塞-释放方案评估微循环反应性。使用放置在下臂的光纤探头连续采集全面的皮肤微循环数据。排除缺失数据（208 例）后，剩余 1557 例受试者。在各项参数中，缺血后皮肤微循环峰值氧饱和度与心血管危险因素的相关性最强。在调整年龄和性别后，分析了峰值氧饱和度与心血管危险因素之间的线性关系。我们发现，血压（收缩压 -0.05[95%CI：-0.10；-0.003]和舒张压 -0.05[-0.10；-0.003]）、BMI -0.18[-0.23；-0.13]、腰围（男性 -0.20[-0.32；-0.16]，女性 -0.18[-0.25；-0.11]）、糖尿病前期 -0.31[-0.49；-0.12]、高血压 -0.30[-0.42；-0.18]、血脂异常 -0.24[-0.40；-0.09]、空腹血糖水平 -0.06[-0.12；-0.01]、HbA1c-0.07[-0.12；-0.02]、甘油三酯水平 -0.09[-0.14；-0.04]、hsCRP-0.12[-0.17；-0.07]和当前吸烟者与从不吸烟者（-0.50[-0.67；-0.34]）与峰值氧饱和度呈负相关。而与峰值氧饱和度呈正相关的是胆固醇水平 0.05[0.005；0.11]和 HDL 0.11[0.06；0.17]。这是第一项表明在基于人群的中年队列中，缺血后皮肤微血管峰值氧饱和度与几乎所有已确立的心血管危险因素相关的研究。
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