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[特发性面神经麻痹(贝尔麻痹)的诊断与治疗]

[Diagnostics and Therapy of Idiopathic Facial Palsy (Bell's Palsy)].

作者信息

Thielker Jovanna, Kuttenreich Anna-Maria, Volk Gerd Fabian, Guntinas-Lichius Orlando

机构信息

Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde, Universitätsklinikum Jena, Jena, Germany.

出版信息

Laryngorhinootologie. 2021 Dec;100(12):1004-1018. doi: 10.1055/a-1529-3582. Epub 2021 Nov 26.

Abstract

The purpose of this review is to report the knowledge for otolaryngologists on standard of care, latest advances, interesting new findings and controversies about the treatment of Bell's palsy. This review is focusing on the acute phase of the disease. The chronic phase, with incomplete, incorrect or no recovery of the palsy, is described briefly. Treatment with prednisolone alone within 72 hours after onset still is the cornerstone of the treatment. The role of antivirals still is unclear. Since 2009 no new and breakthrough clinical trials with influence on the treatment standards have been performed. A study to clarify the role of prednisolone treatment in children is ongoing. Patient-related outcome measures like the Facial Clinimetric Evaluation Scale and the Facial Disability Index are important tools to assess the subjective severity of the disease and psychosocial impact of Bell's palsy next to the motor deficits. Simplified subjective electronic grading systems like the eFACE and first automated image analysis systems have been introduced. Studies clarifying the role of antivirals for severe cases are urgently needed as well as studies on the role of salvage second line therapy after insufficient response to initial corticosteroid treatment. An international consensus on the outcome measures in diagnostics and follow-up is also needed.

摘要

本综述的目的是向耳鼻喉科医生汇报有关贝尔面瘫治疗的护理标准、最新进展、有趣的新发现及争议等知识。本综述聚焦于该病的急性期。对于面瘫恢复不完全、不正确或未恢复的慢性期,将进行简要描述。发病后72小时内单独使用泼尼松龙治疗仍是治疗的基石。抗病毒药物的作用仍不明确。自2009年以来,尚未开展对治疗标准有影响的新的突破性临床试验。一项阐明泼尼松龙治疗在儿童中作用的研究正在进行中。除运动功能缺损外,诸如面部临床测量评估量表和面部残疾指数等与患者相关的结局指标是评估该病主观严重程度及贝尔面瘫社会心理影响的重要工具。已引入了如eFACE等简化的主观电子分级系统以及首个自动图像分析系统。迫切需要开展阐明抗病毒药物对重症病例作用的研究,以及在对初始皮质类固醇治疗反应不足后挽救性二线治疗作用的研究。还需要就诊断和随访中的结局指标达成国际共识。

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