Faculty of Pharmaceutical Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.
Biomolecules. 2021 Nov 4;11(11):1639. doi: 10.3390/biom11111639.
The vitamin D structure consists of the A-ring, a linker originating from the B-ring, C-ring, D-ring, and side-chain moieties. Each unit has its unique role in expressing the biological activities of vitamin D. Many efforts have been made to date to assess the possible clinical use of vitamin D. Some organic chemists focused on the D-ring structure of vitamin D and synthesized D-ring-modified vitamin D analogues, and their biological activities were studied. This review summarizes the synthetic methodologies of D-ring-modified vitamin D analogues, except for -D, and their preliminary biological profiles.
维生素 D 的结构由 A 环、B 环衍生的连接链、C 环、D 环和侧链部分组成。每个单元在表达维生素 D 的生物活性方面都有其独特的作用。迄今为止，人们已经做了很多努力来评估维生素 D 的可能临床用途。一些有机化学家专注于维生素 D 的 D 环结构，并合成了 D 环修饰的维生素 D 类似物，研究了它们的生物活性。本综述总结了除 -D 以外的 D 环修饰的维生素 D 类似物的合成方法及其初步的生物学特征。
