基因、基因和基因的单核苷酸多态性与胎膜早破有关。
Single Nucleotide Polymorphisms from , , and Genes Are Associated with Prelabor Rupture of Membranes.
机构信息
Scientific Laboratory of the Center of Medical Laboratory Diagnostics and Screening, Polish Mother's Memorial Hospital-Research Institute, 281/289 Rzgowska St., 93-338 Lodz, Poland.
Department of Obstetrics and Gynecology, University Hospital Hradec Kralove, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 500 03 Hradec Kralove, Czech Republic.
出版信息
Genes (Basel). 2021 Oct 28;12(11):1725. doi: 10.3390/genes12111725.
A prelabor rupture of membranes (PROM) and its subtypes, preterm PROM (pPROM) and term PROM (tPROM), are associated with disturbances in the hemostatic system and angiogenesis. This study was designed to demonstrate the role of single nucleotide polymorphisms (SNPs), localized in (rs25881), (rs722503), (C-399T) and (rs352140) genes, in PROM. A population of 360 women with singleton pregnancy consisted of 180 PROM cases and 180 healthy controls. A single-SNP analysis showed a similar distribution of genotypes in the studied polymorphisms between the PROM or the pPROM women and the healthy controls. Double-SNP TT variants for and polymorphisms, CC variants for and SNPs, TTC for , and polymorphisms, TTT for , and SNPs and CCCC and TTTC complex variants for all tested SNPs correlated with an increased risk of PROM after adjusting for APTT, PLT parameters and/or pregnancy disorders. The TCT variants for the , and SNPs and the CCTC for the , , and polymorphisms correlated with a reduced risk of PROM when corrected by PLT and APTT, respectively. We concluded that the polymorphisms of genes, involved in hemostasis and angiogenesis, contributed to PROM.
胎膜早破（PROM）及其亚型，早产胎膜早破（pPROM）和足月胎膜早破（tPROM），与止血系统和血管生成的紊乱有关。本研究旨在证明位于 （rs25881）、 （rs722503）、 （C-399T）和 （rs352140）基因中的单核苷酸多态性（SNPs）在 PROM 中的作用。一个由 360 名单胎妊娠妇女组成的人群中，有 180 例 PROM 病例和 180 名健康对照者。单 SNP 分析显示，研究中的多态性在 PROM 或 pPROM 妇女与健康对照组之间的基因型分布相似。对于 和 多态性的 TT 双 SNP 变异体， 和 多态性的 CC 变异体， 和 多态性的 TTC 变异体， 和 多态性的 TTT 变异体，以及所有测试 SNP 的 CCCC 和 TTTC 复合变异体，在调整 APTT、PLT 参数和/或妊娠疾病后，与 PROM 的风险增加相关。对于 、 和 多态性的 TCT 变异体，以及 、 、 多态性的 CCTC 变异体，在分别校正 PLT 和 APTT 后，与 PROM 的风险降低相关。我们得出结论，参与止血和血管生成的基因多态性与 PROM 有关。
Zotero 插件