Rubenstein Sara, Grew Emily, Clouser Katharine, Kwok Alexander, Veerapandiyan Aravindhan, Kornitzer Jeffrey, Pecor Keith, Ming Xue
Department of Neurology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Pediatric Hospital Medicine, Hackensack University Medical Center, Hackensack, NJ 07601, USA.
Children (Basel). 2021 Oct 22;8(11):951. doi: 10.3390/children8110951.
Most cases of COVID-19 in children and adolescents are mild or asymptomatic, but a small number of individuals may develop severe disease, requiring PICU admission and/or mechanical ventilation. We assessed the factors associated with negative short-term outcomes of COVID-19 in 82 pediatric patients at three hospitals within the United States during the spring and summer of 2020 using medical records, laboratory data, and imaging studies of all patients admitted with a positive RT-PCR test for SARS-CoV-2. We found that older patients were more likely to have an extended hospital stay, and those with high BMIs (over 25) were more likely to be admitted to the PICU during the early pandemic. In addition, older patients, those with high BMIs, and those with underlying medical conditions, were more likely to receive respiratory support. Given the association of age, BMI, and underlying medical conditions with more severe COVID-19, clinicians should keep these factors in mind when treating patients.
大多数儿童和青少年的新冠病毒病（COVID-19）病例为轻症或无症状，但少数个体可能发展为重症，需要入住儿科重症监护病房（PICU）和/或接受机械通气。我们利用2020年春夏期间美国三家医院82例儿科患者的病历、实验室数据和影像学研究，评估了与COVID-19短期不良结局相关的因素，这些患者的逆转录聚合酶链反应（RT-PCR）检测结果为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）阳性。我们发现，年龄较大的患者住院时间更有可能延长，且在疫情早期，体重指数（BMI）较高（超过25）的患者更有可能入住PICU。此外，年龄较大的患者、BMI较高的患者以及有基础疾病的患者更有可能接受呼吸支持。鉴于年龄、BMI和基础疾病与更严重的COVID-19相关，临床医生在治疗患者时应牢记这些因素。
