Dyer P A, Ridway J C, Flanagan N G
Tissue Typing Laboratory, St Mary's Hospital, Manchester.
Dis Markers. 1986 Oct;4(3):231-7.
Eighty-three patients with B cell chronic lymphocytic leukaemia were typed for HLA-A,B, and DR antigens. HLA-A2 was found to be significantly increased in patients compared to controls. The frequency of antigens A2,B12(44),DR7 occurring together was more than double the frequency found in the controls. In 48 patients requiring treatment, there was a significant reduction of B8 when compared to 34 untreated patients, and DR7 was significantly increased in frequency in treated patients. Thirty patients presented with sub-clinical symptoms (Rai stage 0). HLA-A10 was significantly more common than in those patients presenting with more advanced disease (Rai stages 1-4). The highest frequency of any HLA antigen was found in males presenting with clinical symptoms, 71.0 per cent of whom were A2 positive; in the same group, 22.6 per cent of patients were positive for all the antigens A2,B12(44),DR7. Patients with an age of onset greater than the mean age of 69 years were more likely to be A2 positive. We conclude that HLA-B8 is a marker of mild disease while HLA-A2 and the closely associated antigens B12(44) and DR7 are markers for severe disease.
对83例B细胞慢性淋巴细胞白血病患者进行了HLA - A、B和DR抗原分型。发现与对照组相比，患者中HLA - A2显著增加。抗原A2、B12(44)、DR7同时出现的频率是对照组的两倍多。在48例需要治疗的患者中，与34例未治疗患者相比，B8显著减少，而治疗患者中DR7的频率显著增加。30例患者表现为亚临床症状（Rai分期0期）。HLA - A10在这些患者中比那些表现为更晚期疾病（Rai分期1 - 4期）的患者中显著更常见。在出现临床症状的男性中发现任何HLA抗原的频率最高，其中71.0%为A2阳性；在同一组中，22.6%的患者A2、B12(44)、DR7所有抗原均为阳性。发病年龄大于平均年龄69岁的患者更可能为A2阳性。我们得出结论，HLA - B8是轻度疾病的标志物，而HLA - A2以及密切相关的抗原B12(44)和DR7是严重疾病的标志物。
