Bellini Maria Irene, Biffoni Marco, Patrone Renato, Borcea Maria Carola, Costanzo Maria Ludovica, Garritano Tiziana, Melcarne Rossella, Menditto Rosa, Metere Alessio, Scorziello Chiara, Summa Marco, Ventrone Luca, D'Andrea Vito, Giacomelli Laura
Azienda Ospedaliera San Camillo Forlanini, 00152 Rome, Italy.
Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
J Clin Med. 2021 Nov 12;10(22):5258. doi: 10.3390/jcm10225258.
There is controversy in the literature regarding a distinct subset of thyroid carcinoma whose histologically classification falls between well-differentiated and anaplastic carcinomas, previously identified as 'poorly differentiated thyroid carcinoma' (PDTC), or 'insular carcinoma', in view of the peculiar morphological characteristics of the cell groupings. The correct diagnosis and treatment of this entity have important prognostic and therapeutic significance. In this review, we describe the epidemiology, diagnosis, and management of PDTC and report our single centre experience to add to the limited evidence existing in the literature.
关于甲状腺癌的一个独特亚组,文献中存在争议。鉴于细胞群的特殊形态特征,其组织学分类介于高分化癌和未分化癌之间,以前被认定为“低分化甲状腺癌”(PDTC)或“岛状癌”。该实体的正确诊断和治疗具有重要的预后和治疗意义。在本综述中,我们描述了PDTC的流行病学、诊断和管理,并报告了我们单中心的经验,以补充文献中现有的有限证据。