Clinical Significance and Prognostic Value of Hemostasis Parameters in 337 Patients with Acute Infective Endocarditis.

(1) Background: The aim of this study was to assess the clinical significance and prognostic role of the main hemostasis parameters in infective endocarditis (IE): prothrombin time as international normalized ratio (PT-INR), activated partial thromboplastin time (aPTT), fibrinogen, D-dimers, platelet count, homocysteine. (2) Methods: We studied 337 patients with IE. Clinical, hemato-chemical and echocardiography parameters were analyzed. Coagulation parameters were measured on admission. (3) Results: D-dimers levels ( = 0.012) and a prolonged PT-INR ( = 0.013) were associated with higher in-hospital mortality, while prolonged aPTT ( = 0.021) was associated with increased 1-year mortality. () infection ( = 0.003), prosthetic valve endocarditis (PVE) ( = 0.001), surgical indication ( = 0.002) and higher D-dimer levels ( = 0.005) were independent predictors of in-hospital mortality. PVE ( = 0.001), a higher Charlson Comorbidity Index ( = 0.049), surgical indication ( = 0.001) and prolonged aPTT ( = 0.012) were independent predictors of 1-year mortality. Higher levels of D-dimers ( < 0.001) and a shorter aPTT ( < 0.001) were associated with embolic complications of IE. etiology was bound to higher D-dimers levels ( < 0.001) and a shorter aPTT ( = 0.006). (4) Conclusions: Elevated D-dimers are associated with a higher risk for in-hospital mortality in IE patients. High D-dimers and a short aPTT are associated with a higher risk for embolic events in IE. A longer aPTT is associated with 1-year mortality.