Kim Minsu, Park Seok Chan, Lee Dong Yun
Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Korea.
Institute of Nano Science & Technology (INST), Hanyang University, Seoul 04763, Korea.
Cancers (Basel). 2021 Nov 17;13(22):5762. doi: 10.3390/cancers13225762.
Chemotherapy is used widely for cancer treatment; however, the evolution of multidrug resistance (MDR) in many patients limits the therapeutic benefits of chemotherapy. It is important to overcome MDR for enhanced chemotherapy. ATP-dependent efflux of drugs out of cells is the main mechanism of MDR. Recent studies have suggested that nitric oxide (NO) can be used to overcome MDR by inhibiting the ATPase function of ATP-dependent pumps. Several attempts have been made to deliver NO to the tumor microenvironment (TME), however there are limitations in delivery. Glycyrrhizin (GL), an active compound of licorice, has been reported to both reduce the MDR effect by inhibiting ATP-dependent pumps and function as a regulator of NO production in the TME. In this review, we describe the potential role of GL as an NO regulator and MDR inhibitor that efficiently reduces the MDR effect in cancer chemotherapy.
化疗被广泛用于癌症治疗；然而，许多患者中多药耐药性（MDR）的演变限制了化疗的治疗效果。克服多药耐药性以增强化疗效果很重要。药物通过ATP依赖的方式流出细胞是多药耐药性的主要机制。最近的研究表明，一氧化氮（NO）可通过抑制ATP依赖泵的ATP酶功能来克服多药耐药性。人们已进行了多次尝试将NO递送至肿瘤微环境（TME），然而在递送方面存在局限性。甘草甜素（GL）是甘草的一种活性化合物，据报道它既能通过抑制ATP依赖泵来降低多药耐药性效应，又能作为肿瘤微环境中NO产生的调节剂。在本综述中，我们描述了甘草甜素作为一种NO调节剂和多药耐药性抑制剂的潜在作用，其能有效降低癌症化疗中的多药耐药性效应。
