Endocrinology, Diabetes and Nutrition Unit, Institute of Experimental and Clinical Research, Medical Sector, Université Catholique de Louvain, 1200 Brussels, Belgium.
Neuromuscular Reference Center, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium.
Cells. 2021 Nov 4;10(11):3023. doi: 10.3390/cells10113023.
Over the last decade, innate immune system receptors and sensors called inflammasomes have been identified to play key pathological roles in the development and progression of numerous diseases. Among them, the nucleotide-binding oligomerization domain (NOD-), leucine-rich repeat (LRR-) and pyrin domain-containing protein 3 (NLRP3) inflammasome is probably the best characterized. To date, NLRP3 has been extensively studied in the heart, where its effects and actions have been broadly documented in numerous cardiovascular diseases. However, little is still known about NLRP3 implications in muscle disorders affecting non-cardiac muscles. In this review, we summarize and present the current knowledge regarding the function of NLRP3 in diseased skeletal muscle, and discuss the potential therapeutic options targeting the NLRP3 inflammasome in muscle disorders.
在过去的十年中，已经确定了先天免疫系统受体和传感器，称为炎性小体，它们在许多疾病的发展和进展中发挥关键的病理作用。其中，核苷酸结合寡聚结构域（NOD-）、富含亮氨酸重复（LRR-）和吡咯烷域包含蛋白 3（NLRP3）炎性小体可能是研究得最好的。迄今为止，NLRP3 在心脏中已经得到了广泛的研究，其在许多心血管疾病中的作用和作用已经得到了广泛的记录。然而，对于 NLRP3 在影响非心肌的肌肉疾病中的作用仍然知之甚少。在这篇综述中，我们总结并介绍了 NLRP3 在患病骨骼肌中的功能的最新知识，并讨论了针对肌肉疾病中 NLRP3 炎性小体的潜在治疗选择。
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