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乳杆菌用于核糖体肽编辑癌症。

Lactobacillus for ribosome peptide editing cancer.

机构信息

Biotechnology Research Center, Shandong Academy of Agricultural Sciences, 202 Gongye North Road, Jinan, 250100, Shandong, China.

Science and Technology Service Platform of Shandong Academy of Sciences, Shandong Academy of Sciences Foreign Students Pioneer Park, Jinan, 250103, Shandong, China.

出版信息

Clin Transl Oncol. 2023 Jun;25(6):1522-1544. doi: 10.1007/s12094-022-03066-5. Epub 2023 Jan 24.

DOI:10.1007/s12094-022-03066-5
PMID:36694080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9873400/
Abstract

This study reviews newly discovered insect peptide point mutations as new possible cancer research targets. To interpret newly discovered peptide point mutations in insects as new possible cancer research targets, we focused on the numerous peptide changes found in the 'CSP' family on the sex pheromone gland of the female silkworm moth Bombyx mori. We predict that the Bombyx peptide modifications will have a significant effect on cancer CUP (cancers of unknown primary) therapy and that bacterial peptide editing techniques, specifically Lactobacillus combined to CRISPR, will be used to regulate ribosomes and treat cancer in humans.

摘要

本研究综述了新发现的昆虫肽点突变作为新的潜在癌症研究靶点。为了解释昆虫中新发现的肽点突变作为新的潜在癌症研究靶点，我们专注于在雌性家蚕蛾 B. mori 的性信息素腺中发现的“CSP”家族中的大量肽变化。我们预测，家蚕肽修饰将对癌症 CUP（不明原发灶的癌症）治疗产生重大影响，并且细菌肽编辑技术，特别是与 CRISPR 结合的乳酸杆菌，将用于调节核糖体并治疗人类癌症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaac/9873400/a63d2f76ef87/12094_2022_3066_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaac/9873400/3a4dad5f9d5b/12094_2022_3066_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaac/9873400/9fcf75fa3528/12094_2022_3066_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaac/9873400/367c40e4cb06/12094_2022_3066_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaac/9873400/a63d2f76ef87/12094_2022_3066_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaac/9873400/3a4dad5f9d5b/12094_2022_3066_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaac/9873400/9fcf75fa3528/12094_2022_3066_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaac/9873400/367c40e4cb06/12094_2022_3066_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaac/9873400/a63d2f76ef87/12094_2022_3066_Fig4_HTML.jpg

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Lactobacillus for ribosome peptide editing cancer.乳杆菌用于核糖体肽编辑癌症。
Clin Transl Oncol. 2023 Jun;25(6):1522-1544. doi: 10.1007/s12094-022-03066-5. Epub 2023 Jan 24.
2
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本文引用的文献

1
Interplay between A-to-I Editing and Splicing of RNA: A Potential Point of Application for Cancer Therapy.RNA 的 A-to-I 编辑与剪接之间的相互作用：癌症治疗的潜在应用点。
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CRISPR in cancer biology and therapy.CRISPR在癌症生物学与治疗中的应用
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Current applications and future perspective of CRISPR/Cas9 gene editing in cancer.CRISPR/Cas9 基因编辑在癌症中的当前应用和未来展望。
Mol Cancer. 2022 Feb 21;21(1):57. doi: 10.1186/s12943-022-01518-8.
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Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.最小真核核糖体结构中对基因组退化的适应。
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CRISPR editing within microbial communities.微生物群落中的CRISPR编辑
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Walking down Skeletal Muscle Lane: From Inflammasome to Disease.沿着骨骼肌小路前行：从炎症小体到疾病。
Cells. 2021 Nov 4;10(11):3023. doi: 10.3390/cells10113023.
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Stem cells part of the innate and adaptive immune systems as a therapeutic for Covid-19.作为治疗新冠肺炎的一种手段，干细胞是先天免疫系统和适应性免疫系统的一部分。
Commun Integr Biol. 2021 Sep 10;14(1):186-198. doi: 10.1080/19420889.2021.1965356. eCollection 2021.
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Transcriptome-Wide Identification of G-to-A RNA Editing in Chronic Social Defeat Stress Mouse Models.慢性社会挫败应激小鼠模型中全转录组范围的G-to-A RNA编辑鉴定
Front Genet. 2021 May 19;12:680548. doi: 10.3389/fgene.2021.680548. eCollection 2021.
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Adaptive Proteome Diversification by Nonsynonymous A-to-I RNA Editing in Coleoid Cephalopods.头足类动物中非同义 A-to-I RNA 编辑的适应性蛋白质组多样化。
Mol Biol Evol. 2021 Aug 23;38(9):3775-3788. doi: 10.1093/molbev/msab154.
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A synthetic RNA editing factor edits its target site in chloroplasts and bacteria.一种合成的 RNA 编辑因子编辑其在叶绿体和细菌中的靶位点。
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