Biotechnology Research Center, Shandong Academy of Agricultural Sciences, 202 Gongye North Road, Jinan, 250100, Shandong, China.
Science and Technology Service Platform of Shandong Academy of Sciences, Shandong Academy of Sciences Foreign Students Pioneer Park, Jinan, 250103, Shandong, China.
Clin Transl Oncol. 2023 Jun;25(6):1522-1544. doi: 10.1007/s12094-022-03066-5. Epub 2023 Jan 24.
This study reviews newly discovered insect peptide point mutations as new possible cancer research targets. To interpret newly discovered peptide point mutations in insects as new possible cancer research targets, we focused on the numerous peptide changes found in the 'CSP' family on the sex pheromone gland of the female silkworm moth Bombyx mori. We predict that the Bombyx peptide modifications will have a significant effect on cancer CUP (cancers of unknown primary) therapy and that bacterial peptide editing techniques, specifically Lactobacillus combined to CRISPR, will be used to regulate ribosomes and treat cancer in humans.
本研究综述了新发现的昆虫肽点突变作为新的潜在癌症研究靶点。为了解释昆虫中新发现的肽点突变作为新的潜在癌症研究靶点,我们专注于在雌性家蚕蛾 B. mori 的性信息素腺中发现的“CSP”家族中的大量肽变化。我们预测,家蚕肽修饰将对癌症 CUP(不明原发灶的癌症)治疗产生重大影响,并且细菌肽编辑技术,特别是与 CRISPR 结合的乳酸杆菌,将用于调节核糖体并治疗人类癌症。