da Silva Everton M, Vidal Hérika D A, Corrêa Arlene G
Centre of Excellence for Research on Sustainable Chemistry, Department of Chemistry, Federal University of São Carlos, São Carlos 13565-905, SP, Brazil.
Pharmaceuticals (Basel). 2021 Nov 4;14(11):1125. doi: 10.3390/ph14111125.
Viral infections cause many severe human diseases, being responsible for remarkably high mortality rates. In this sense, both the academy and the pharmaceutical industry are continuously searching for new compounds with antiviral activity, and in addition, face the challenge of developing greener and more efficient methods to synthesize these compounds. This becomes even more important with drugs possessing stereogenic centers as highly enantioselective processes are required. In this minireview, the advances achieved to improve synthetic routes efficiency and sustainability of important commercially antiviral chiral drugs are discussed, highlighting the use of organocatalytic methods.
病毒感染引发了许多严重的人类疾病，导致极高的死亡率。从这个意义上讲，学术界和制药行业都在不断寻找具有抗病毒活性的新化合物，此外，还面临着开发更绿色、更高效的方法来合成这些化合物的挑战。对于具有立体中心的药物而言，由于需要高度对映选择性的过程，这一点变得尤为重要。在这篇综述中，我们讨论了在提高重要商业抗病毒手性药物合成路线效率和可持续性方面所取得的进展，重点介绍了有机催化方法的应用。
