State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, China.
Collaborative Innovation Center of Chemical Science, and Engineering, Tianjin, China.
Angew Chem Int Ed Engl. 2019 May 20;58(21):6818-6825. doi: 10.1002/anie.201808700. Epub 2019 Mar 12.
Organocatalytic methods have achieved spectacular advancements for the preparation of chiral molecules in highly enantioenriched forms. The fast development of this field can mainly be attributed to the evolution of general and reliable activation modes. The discovery and identification of new activation modes are therefore highly desirable to push the boundaries of asymmetric reactions. In this Minireview, recent advances in enantioselective carbonyl catalysis, one useful subbranch of organocatalysis for the efficient activation of simple amines, will be summarized. With elegantly designed chiral aldehyde catalysts, highly enantioselective and efficient asymmetric reactions can be developed. Continued development of enantioselective carbonyl catalysis is expected in the future.
有机催化方法在制备手性分子的高对映体富集形式方面取得了显著的进展。该领域的快速发展主要归因于通用且可靠的活化模式的发展。因此，发现和识别新的活化模式对于推动不对称反应的发展具有重要意义。在这篇综述中，将总结手性醛催化剂在不对称羰基催化中的最新进展，这是有机催化中用于有效活化简单胺的一个有用分支。通过精心设计的手性醛催化剂，可以开发出高度对映选择性和高效的不对称反应。预计未来手性羰基催化的发展将继续。
