Autsavapromporn Narongchai, Klunklin Pitchayaponne, Chitapanarux Imjai, Jaikang Churdsak, Chewaskulyong Busyamas, Sripan Patumrat, Hosoda Masahiro, Tokonami Shinji
Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Toxicology Section, Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Life (Basel). 2021 Nov 21;11(11):1273. doi: 10.3390/life11111273.
Radon is a major cause of lung cancer (LC) deaths among non-smokers worldwide. However, no serum biomarker for screening of LC risk in high residential radon (HRR) areas is available. Therefore, the aim of this study was to determine diagnostic values of serum carcinoembryonic antigen (CEA), cytokeratin 19 fragment (Cyfra21-1), human epididymis protein 4 (HE4), interleukin 8 (IL-8), migration inhibitory factor (MIF), tumor nuclear factor-alpha (TNF-α) and vascular endothelial growth factors (VEGF) occurring in high radon areas. Seventy-five LC non-smoker patients and seventy-five healthy controls (HC) were enrolled in this study. Among the HC groups, twenty-five HC were low residential radon (LRR) and fifty HC were HRR. Significantly higher ( < 0.0004) serum levels of CEA, Cyfra21-1, IL-8 and VEGF were found in the LC compared with the LRR and HRR groups. More importantly, significantly higher levels ( < 0.009) of serum CEA, Cyfra21-1 and IL-8 were observed in HRR compared with the LRR group. Likewise, a ROC curve demonstrated that serum CEA and Cyfra21-1 could better distinguish LC risk from HRR groups than IL-8. These results indicated that serum CEA and Cyfra21-1 were significantly increased in the HRR group and may be considered as potential biomarkers for individuals at high-risk to develop LC.
氡是全球非吸烟者肺癌（LC）死亡的主要原因。然而，目前尚无用于筛查高居住氡（HRR）地区LC风险的血清生物标志物。因此，本研究的目的是确定血清癌胚抗原（CEA）、细胞角蛋白19片段（Cyfra21-1）、人附睾蛋白4（HE4）、白细胞介素8（IL-8）、迁移抑制因子（MIF）、肿瘤核因子-α（TNF-α）和血管内皮生长因子（VEGF）在高氡地区的诊断价值。本研究纳入了75例非吸烟LC患者和75例健康对照（HC）。在HC组中，25例HC为低居住氡（LRR），50例HC为HRR。与LRR组和HRR组相比，LC组血清CEA、Cyfra21-1、IL-8和VEGF水平显著升高（<0.0004）。更重要的是，与LRR组相比，HRR组血清CEA、Cyfra21-1和IL-8水平显著升高（<0.009）。同样，ROC曲线表明，血清CEA和Cyfra21-1比IL-8能更好地区分HRR组的LC风险。这些结果表明，HRR组血清CEA和Cyfra21-1显著升高，可被视为发生LC高危个体的潜在生物标志物。
