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用于III-B型轮烷树枝状大分子的功能性结构单元的合成。

Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer.

作者信息

Kwan Chak-Shing, Ho Watson K-W, Chen Yanyan, Cai Zongwei, Leung Ken Cham-Fai

机构信息

State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, The Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, China.

Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.

出版信息

Polymers (Basel). 2021 Nov 12;13(22):3909. doi: 10.3390/polym13223909.

DOI:10.3390/polym13223909
PMID:34833208
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8622516/
Abstract

Second-generation type III-B rotaxane dendrons, equipped with succinimide and acetylene functional groups, were synthesized successfully and characterized by NMR spectroscopy and mass spectrometry. A cell viability study of a dendron with a normal cell line of L929 fibroblast cells revealed no obvious cytotoxicity at a range of 5 to 100 μM. The nontoxic properties of the sophisticated rotaxane dendron building blocks provided a choice of bio-compatible macromolecular machines that could be potentially developed into polymeric materials.

摘要

成功合成了配备琥珀酰亚胺和乙炔官能团的第二代III-B型轮烷树枝状分子，并通过核磁共振光谱和质谱对其进行了表征。对一种带有L929成纤维细胞正常细胞系的树枝状分子进行的细胞活力研究表明，在5至100μM的浓度范围内没有明显的细胞毒性。这种复杂的轮烷树枝状分子构建块的无毒特性为生物相容性高分子机器提供了一种选择，这些机器有可能被开发成聚合物材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/358a/8622516/171a76755a6f/polymers-13-03909-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/358a/8622516/9e3b59048712/polymers-13-03909-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/358a/8622516/8f7b2262e67a/polymers-13-03909-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/358a/8622516/31c5f7fa0472/polymers-13-03909-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/358a/8622516/93486002e2ee/polymers-13-03909-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/358a/8622516/eb389fb6915c/polymers-13-03909-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/358a/8622516/171a76755a6f/polymers-13-03909-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/358a/8622516/9e3b59048712/polymers-13-03909-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/358a/8622516/8f7b2262e67a/polymers-13-03909-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/358a/8622516/31c5f7fa0472/polymers-13-03909-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/358a/8622516/93486002e2ee/polymers-13-03909-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/358a/8622516/eb389fb6915c/polymers-13-03909-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/358a/8622516/171a76755a6f/polymers-13-03909-g006.jpg

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