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阵发性心房颤动首次射频导管消融干预后心房颤动复发的预测因素-低容量消融中心的经验。

Predictors of Atrial Fibrillation Recurrences after a First Radiofrequency Catheter Ablation Intervention for Paroxysmal Atrial Fibrillation-Experience of a Low Volume Ablation Centre.

机构信息

Cardiothoracic Pathology Department, University of Medicine and Pharmacy Carol Davila, 020021 Bucharest, Romania.

Department of Cardiology, Elias Emergency University Hospital, 011461 Bucharest, Romania.

出版信息

Medicina (Kaunas). 2021 Oct 20;57(11):1139. doi: 10.3390/medicina57111139.

DOI:10.3390/medicina57111139
PMID:34833357
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8618952/
Abstract

Atrial fibrillation recurrences (AFR) after radiofrequency catheter ablation (RFCA) are not uncommon, up to 65% of patients having relapses in the first year. However, current data are based mainly on studies from centres with a large volume of ablations, as they include technically inhomogeneous interventions, and populations with different types of AF. The aim of our study was to assess and stratify the risk at 6 and 12 months for AFR after a single RFCA, in patients with paroxysmal AF, in a centre with low volume activity. We enrolled 40 patients who underwent an initial RFCA, followed by continuous 48 h ECG monitoring at 1, 3, 6, and 12 months. Patients self-monitored their cardiac activity by random daily radial pulse palpation or in the presence of palpitations. Ten independent predictors for late AFR were identified, and a 6-month risk score was computed using three of them: AFR duration in the first month, number of AFR between 1 and 3 months, and supraventricular ectopics per 24 h at 6 months. The score can explain 59% of the AFR ( = 0.001). A further 12-month assessment identified three independent predictors. The presence of AFR between 6-12 months is the most important of them (OR = 23.11, 95% CI = 3.87-137.83, = 0.001), explaining 45% of AFR over 1 year. The risk scores at 6 and 12 months were internally validated. The 6-month score proved to be a useful tool in guiding further strategy for patients with a low risk, while a longer follow-up to 12 months may avoid unnecessary early reinterventions.

摘要

心房颤动(AF)射频导管消融(RFCA)后复发并不少见,多达 65%的患者在第一年复发。然而,目前的数据主要基于大型消融中心的研究,因为它们包括技术上不均匀的干预措施,以及不同类型 AF 的人群。我们的研究目的是评估和分层阵发性 AF 患者单次 RFCA 后 6 个月和 12 个月 AF 复发的风险,该研究在低容量活动中心进行。我们纳入了 40 名接受初始 RFCA 的患者,随后在 1、3、6 和 12 个月进行连续 48 小时心电图监测。患者通过随机每日桡动脉搏动触诊或心悸时自行监测心脏活动。确定了 10 个晚期 AF 复发的独立预测因素,并使用其中 3 个因素计算了 6 个月风险评分:第一个月的 AF 持续时间、1 至 3 个月之间的 AF 次数以及 6 个月时每 24 小时的室上性早搏次数。该评分可以解释 59%的 AF( = 0.001)。进一步的 12 个月评估确定了三个独立的预测因素。6-12 个月之间存在 AF 是最重要的预测因素(OR = 23.11,95%CI = 3.87-137.83, = 0.001),可以解释 1 年内 45%的 AF。6 个月和 12 个月的风险评分均进行了内部验证。6 个月评分可作为指导低风险患者进一步策略的有用工具,而 12 个月的更长随访可能避免不必要的早期再介入。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ef/8618952/f883e074c7c3/medicina-57-01139-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ef/8618952/ea789b9364a6/medicina-57-01139-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ef/8618952/62e9d594bfd8/medicina-57-01139-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ef/8618952/82948ea0acec/medicina-57-01139-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ef/8618952/f883e074c7c3/medicina-57-01139-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ef/8618952/ea789b9364a6/medicina-57-01139-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ef/8618952/62e9d594bfd8/medicina-57-01139-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ef/8618952/82948ea0acec/medicina-57-01139-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ef/8618952/f883e074c7c3/medicina-57-01139-g005.jpg

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Eur Heart J. 2021 Feb 1;42(5):373-498. doi: 10.1093/eurheartj/ehaa612.
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