Balado Miguel, Rey-Varela Diego, Albela Ana M, Lemos Manuel L
Department of Microbiology and Parasitology, Institute of Aquaculture, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Microorganisms. 2021 Nov 21;9(11):2399. doi: 10.3390/microorganisms9112399.
Bismuth is a heavy metal with antibacterial properties that has a long history of medicinal use. The results reported here suggest that bismuth(III) (chelated with deferiprone) could be used in aquaculture systems to treat bacterial disease outbreaks, greatly reducing antibiotic use. We tested bismuth susceptibility in a collection of aquaculture bacterial pathogens. In the presence of bismuth concentrations ranging from 1.3 to 13 µM, most bacteria started showing a drastic decrease in their growth ability, although with high inter- and intraspecific variability. The minimal inhibitory concentrations of bismuth ranged from 13 to more than 780 µM, depending on bacterial species and strain. The results of in vivo assays suggest that low concentrations of bismuth could be especially effective to treat vibriosis caused by since bismuth greatly reduced mortality in experimentally infected fish without any observable side effects. A bismuth therapy, alone or combined with other antimicrobials, could contribute to reduce the use of antibiotics in aquaculture.
铋是一种具有抗菌特性的重金属，其药用历史悠久。此处报告的结果表明，铋（III）（与去铁酮螯合）可用于水产养殖系统，以治疗细菌性疾病爆发，从而大幅减少抗生素的使用。我们检测了一系列水产养殖细菌病原体对铋的敏感性。在铋浓度为1.3至13 μM的情况下，大多数细菌开始表现出其生长能力的急剧下降，尽管种间和种内差异很大。铋的最低抑菌浓度范围为13至780 μM以上，具体取决于细菌种类和菌株。体内试验结果表明，低浓度的铋可能对治疗由[病原体名称未给出]引起的弧菌病特别有效，因为铋可大大降低实验感染鱼类的死亡率，且无任何明显副作用。铋疗法单独使用或与其他抗菌剂联合使用，有助于减少水产养殖中抗生素的使用。
