Oluwasanmi Adeolu, Man Ernest, Curtis Anthony, Yiu Humphrey H P, Perrie Yvonne, Hoskins Clare
Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1RD, UK.
School of Pharmacy and Bioengineering, Keele University, Keele ST5 5BG, UK.
Nanomaterials (Basel). 2021 Nov 5;11(11):2976. doi: 10.3390/nano11112976.
Hybrid iron oxide-gold nanoparticles are of increasing interest for applications in nanomedicine, photonics, energy storage, etc. However, they are often difficult to synthesise without experience or 'know-how'. Additionally, standard protocols do not allow for scale up, and this is significantly hindering their future potential. In this study, we seek to determine whether microfluidics could be used as a new manufacturing process to reliably produce hybrid nanoparticles with the line of sight to their continuous manufacture and scaleup. Using a Precision Nano NanoAssemblr Benchtop system, we were able to perform the intermediate coating steps required in order to construct hybrid nanoparticles around 60 nm in size with similar chemical and physical properties to those synthesised in the laboratory using standard processes, with Fe/Au ratios of 1:0.6 (standard) and 1:0.7 (microfluidics), indicating that the process was suitable for their manufacture with optimisation required in order to configure a continuous manufacturing plant.
混合氧化铁-金纳米颗粒在纳米医学、光子学、能量存储等领域的应用越来越受到关注。然而，没有经验或“技术诀窍”的话，它们往往很难合成。此外，标准方案无法扩大规模，这严重阻碍了它们未来的潜力。在本研究中，我们试图确定微流体技术是否可以用作一种新的制造工艺，以可靠地生产混合纳米颗粒，并着眼于它们的连续制造和扩大规模。使用Precision Nano NanoAssemblr台式系统，我们能够执行构建尺寸约为60 nm的混合纳米颗粒所需的中间涂层步骤，这些纳米颗粒具有与使用标准工艺在实验室合成的纳米颗粒相似的化学和物理性质，铁/金比例分别为1:0.6（标准）和1:0.7（微流体），这表明该工艺适合制造这些纳米颗粒，但需要进行优化以配置连续制造工厂。
