Graziani Vittoria, Rodriguez-Hernandez Irene, Maiques Oscar, Sanz-Moreno Victoria
Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.
Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.
Trends Cell Biol. 2022 Mar;32(3):228-242. doi: 10.1016/j.tcb.2021.10.004. Epub 2021 Nov 23.
Cell migration is essential for many biological processes, while abnormal cell migration is characteristic of cancer cells. Epithelial cells become motile by undergoing epithelial-to-mesenchymal transition (EMT), and mesenchymal cells increase migration speed by adopting amoeboid features. This review highlights how amoeboid behaviour is not merely a migration mode but rather a cellular state - within the EMT spectra - by which cancer cells survive, invade and colonise challenging microenvironments. Molecular biomarkers and physicochemical triggers associated with amoeboid behaviour are discussed, including an amoeboid associated tumour microenvironment. We reflect on how amoeboid characteristics support metastasis and how their liabilities could turn into therapeutic opportunities.
细胞迁移对许多生物学过程至关重要，而异常的细胞迁移是癌细胞的特征。上皮细胞通过经历上皮-间质转化（EMT）而变得具有运动性，间充质细胞则通过采用阿米巴样特征来提高迁移速度。本综述强调了阿米巴样行为不仅是一种迁移模式，更是一种细胞状态——在EMT谱内——癌细胞通过这种状态在具有挑战性的微环境中存活、侵袭和定植。讨论了与阿米巴样行为相关的分子生物标志物和物理化学触发因素，包括与阿米巴样相关的肿瘤微环境。我们思考了阿米巴样特征如何支持转移以及它们的弱点如何转化为治疗机会。
